Triterpenoids and steroids from ganoderma mastoporum and their inhibitory effects on superoxide anion generation and elastase release

Tran Dinh Thang, Ping Chung Kuo, Tsong Long Hwang, Mei Lin Yang, Nguyen Thi Bich Ngoc, Tran Thi Ngoc Han, Chi Wen Lin, Tian Shung Wu

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The methanol extracts of the fruiting bodies of Ganoderma mastoporum collected in Vietnam was purified to afford eight compounds, including three triterpenoids and five steroids. The purified compounds were examined for their inhibitory effects against superoxide anion generation and elastase release. Among the tested compounds, ergosta-4,6,8(14),22-tetraen-3-one (3) exhibited the most significant inhibition towards superoxide anion generation and elastase release with IC50 values of 2.30 ± 0.38 and 1.94 ± 0.50 μg/mL, respectively.

Original languageEnglish
Pages (from-to)14285-14292
Number of pages8
JournalMolecules
Volume18
Issue number11
DOIs
Publication statusPublished - 2013 Nov

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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