TY - JOUR
T1 - Troponin T levels in baboons with pig heterotopic heart transplants
AU - Kuwaki, K.
AU - Knosalla, C.
AU - Dor, F. J.M.F.
AU - Gollackner, B.
AU - Tseng, Y. L.
AU - Houser, S.
AU - Cooper, D. K.C.
N1 - Funding Information:
We thank D.H. Sachs and L. H. Buhler for their valuable comments on this manuscript. We acknowledge the following grants: Deutsche Forschungsgemeinschaft (KN518,1-1 to CK), Ter Meulen Fund from the Royal Netherlands Academy of Arts and Sciences, Prof. Michal̈-van Vloten Fund, the Netherland-America Foundation (FJMFD), Max Kade Foundation of the Austrian Academy of Science (BG), NIH Program Project 1PO1 A145897, and a Sponsored Research Agreement between the Massachusetts General Hospital and Immerge Biotherapeutics, Inc. D.K.C.C. is a consultant with Immerge BioTherapeutics, Inc.
PY - 2005/1
Y1 - 2005/1
N2 - Troponin T levels have been monitored in baboons (n = 8) undergoing pig heterotopic heart transplantation, and correlated with a decrease in graft contractions and graft survival. Pig heart graft survival was from 12 to 139 days (mean 45, median 33), and graft failure was associated with predominant thrombotic microangiopathy and ischemia, with focal hemorrhage, and edema. An increase in troponin T levels 5 to 6 days before graft failure correlated closely with diminished graft contractions. An increase in troponin T was a reliable indicator that graft dysfunction was occurring.
AB - Troponin T levels have been monitored in baboons (n = 8) undergoing pig heterotopic heart transplantation, and correlated with a decrease in graft contractions and graft survival. Pig heart graft survival was from 12 to 139 days (mean 45, median 33), and graft failure was associated with predominant thrombotic microangiopathy and ischemia, with focal hemorrhage, and edema. An increase in troponin T levels 5 to 6 days before graft failure correlated closely with diminished graft contractions. An increase in troponin T was a reliable indicator that graft dysfunction was occurring.
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U2 - 10.1016/j.healun.2003.09.039
DO - 10.1016/j.healun.2003.09.039
M3 - Article
C2 - 15653386
AN - SCOPUS:11844271428
SN - 1053-2498
VL - 24
SP - 92
EP - 94
JO - Journal of Heart and Lung Transplantation
JF - Journal of Heart and Lung Transplantation
IS - 1
ER -