True color blood flow imaging using a high-speed laser photography system

Chien-Sheng Liu, Cheng Hsien Lin, Yung-Nien Sun, Chung-Liang Ho, Chung Chi Hsu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Physiological changes in the retinal vasculature are commonly indicative of such disorders as diabetic retinopathy, glaucoma, and age-related macular degeneration. Thus, various methods have been developed for noninvasive clinical evaluation of ocular hemodynamics. However, to the best of our knowledge, current ophthalmic instruments do not provide a true color blood flow imaging capability. Accordingly, we propose a new method for the true color imaging of blood flow using a high-speed pulsed laser photography system. In the proposed approach, monochromatic images of the blood flow are acquired using a system of three cameras and three color lasers (red, green, and blue). A highquality true color image of the blood flow is obtained by assembling the monochromatic images by means of image realignment and color calibration processes. The effectiveness of the proposed approach is demonstrated by imaging the flow of mouse blood within a microfluidic channel device. The experimental results confirm the proposed system provides a high-quality true color blood flow imaging capability, and therefore has potential for noninvasive clinical evaluation of ocular hemodynamics.

Original languageEnglish
Article number103201
JournalOptical Engineering
Volume51
Issue number10
DOIs
Publication statusPublished - 2012 Oct 1

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photography
Photography
blood flow
Blood
high speed
Color
color
Imaging techniques
Lasers
lasers
hemodynamics
Hemodynamics
glaucoma
degeneration
evaluation
assembling
Pulsed lasers
Microfluidics
blood
mice

All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics
  • Engineering(all)

Cite this

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True color blood flow imaging using a high-speed laser photography system. / Liu, Chien-Sheng; Lin, Cheng Hsien; Sun, Yung-Nien; Ho, Chung-Liang; Hsu, Chung Chi.

In: Optical Engineering, Vol. 51, No. 10, 103201, 01.10.2012.

Research output: Contribution to journalArticle

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AU - Liu, Chien-Sheng

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AU - Hsu, Chung Chi

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