Tumor-associated hypercalcemia in a patient with Paget's disease

Hao Chang Hung, Horng Yih Ou, Jehn Shyun Huang, Ming Che Chuang, Ta Jen Wu

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Paget's disease of the bone, which is characterized by a focal region of highly exaggerated bone remodeling, is very rare in Asia. Most patients with Paget's disease are asymptomatic; they are normocalcemic and show elevated alkaline phosphatase levels. Hypercalcemia in patients with Paget's disease has rarely been reported. We report one Chinese patient with Paget's disease involving the maxilla bone with an initial presentation of facial cellulitis. Asymptomatic hypercalcemia with a low-normal intact parathyroid hormone level developed 9 years later. After clodronate treatment, the level of alkaline phosphatase normalized, but the hypercalcemia did not respond adequately. After analysis of tumor markers and imaging studies, a clinical diagnosis of pancreatic adenocarcinoma with multiple hepatic and lung metastases with pleural effusion was made. We suggest that malignancy-associated hypercalcemia should be considered as one of the causes of hypercalcemia in patients with Paget's disease.

Original languageEnglish
Pages (from-to)152-156
Number of pages5
JournalKaohsiung Journal of Medical Sciences
Volume24
Issue number3
DOIs
Publication statusPublished - 2008 Mar

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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