Little is known about the response of neural progenitors to inflammation following injuries of the central nervous system. In combination with bromodeoxyuridine (BrdU) intraperitoneally (i.p.) injected, tumor necrosis factor-α (TNF-α), a proinflammatory cytokine that increased ED1+ activated microglia/macrophage population at injured sites, was administrated into adult rat brains. No difference in the immunostaining for proliferating cell nuclear antigen (PCNA) was observed in the subventricular/ventricular zone (SVZ/VZ) between TNF-α injected sites and controls. However, BrdU+ cells were apparently observed in the SVZ/VZ proximal to TNF-α injected site, and the number of BrdU+ cells increased at 6 and 24 h post injection. Since cell apoptosis was rarely found in the SVZ/VZ after TNF-α injection, these observations suggest that the diffusible TNF-α may directly and/or indirectly modulate the proliferation of neural progenitors. (C) 2000 Elsevier Science Ireland Ltd.
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