Tumor necrosis factor-alpha modulates the proliferation of neural progenitors in the subventricular/ventricular zone of adult rat brain

Jen Pey Wu, Jon Son Kuo, Yuh Ling Liu, Shun Fen Tzeng

Research output: Contribution to journalArticlepeer-review

72 Citations (Scopus)

Abstract

Little is known about the response of neural progenitors to inflammation following injuries of the central nervous system. In combination with bromodeoxyuridine (BrdU) intraperitoneally (i.p.) injected, tumor necrosis factor-α (TNF-α), a proinflammatory cytokine that increased ED1+ activated microglia/macrophage population at injured sites, was administrated into adult rat brains. No difference in the immunostaining for proliferating cell nuclear antigen (PCNA) was observed in the subventricular/ventricular zone (SVZ/VZ) between TNF-α injected sites and controls. However, BrdU+ cells were apparently observed in the SVZ/VZ proximal to TNF-α injected site, and the number of BrdU+ cells increased at 6 and 24 h post injection. Since cell apoptosis was rarely found in the SVZ/VZ after TNF-α injection, these observations suggest that the diffusible TNF-α may directly and/or indirectly modulate the proliferation of neural progenitors. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)203-206
Number of pages4
JournalNeuroscience Letters
Volume292
Issue number3
DOIs
Publication statusPublished - 2000 Oct 13

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Tumor necrosis factor-alpha modulates the proliferation of neural progenitors in the subventricular/ventricular zone of adult rat brain'. Together they form a unique fingerprint.

Cite this