Tumor suppressor gene glycine N-methyltransferase and its potential in liver disorders and hepatocellular carcinoma

Marcelo Chen, Ming Hui Yang, Ming-Min Chang, Yu Chang Tyan, Yi Ming Arthur Chen

Research output: Contribution to journalReview article

Abstract

Glycine N-methyltransferase is a protein with many functions. In addition to catalyzing the production of sarcosine in the one carbon metabolism pathway, it plays a role in the detoxification of environmental carcinogens such as benzo[a]pyrene, aflatoxin B1, and aristocholic acid. There is also increasing evidence suggesting a role of GNMT deficiency in liver carcinogenesis. In this review, we discuss the role of GNMT in the detoxification of xenobiotics and the mechanism of GNMT suppression during liver tumorigenesis. The protective role of GNMT in the liver allows GNMT to not only serve as a marker of liver disease, but also potentially be applied in the treatment of liver disorders and hepatocellular carcinoma. We describe the potential use of GNMT in gene therapy and we introduce the development of a GNMT promoter reporter assay that can be used to screen medicinal drugs and herbal libraries for natural compounds with anti-cancer properties.

Original languageEnglish
Article number114607
JournalToxicology and Applied Pharmacology
Volume378
DOIs
Publication statusPublished - 2019 Sep 1

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Glycine N-Methyltransferase
Tumor Suppressor Genes
Liver
Tumors
Hepatocellular Carcinoma
Genes
Detoxification
Carcinogenesis
Sarcosine
Environmental Carcinogens
Aflatoxin B1
Benzo(a)pyrene
Xenobiotics
Gene therapy
Genetic Therapy
Libraries
Liver Diseases
Carbon
Metabolism
Assays

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pharmacology

Cite this

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abstract = "Glycine N-methyltransferase is a protein with many functions. In addition to catalyzing the production of sarcosine in the one carbon metabolism pathway, it plays a role in the detoxification of environmental carcinogens such as benzo[a]pyrene, aflatoxin B1, and aristocholic acid. There is also increasing evidence suggesting a role of GNMT deficiency in liver carcinogenesis. In this review, we discuss the role of GNMT in the detoxification of xenobiotics and the mechanism of GNMT suppression during liver tumorigenesis. The protective role of GNMT in the liver allows GNMT to not only serve as a marker of liver disease, but also potentially be applied in the treatment of liver disorders and hepatocellular carcinoma. We describe the potential use of GNMT in gene therapy and we introduce the development of a GNMT promoter reporter assay that can be used to screen medicinal drugs and herbal libraries for natural compounds with anti-cancer properties.",
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Tumor suppressor gene glycine N-methyltransferase and its potential in liver disorders and hepatocellular carcinoma. / Chen, Marcelo; Yang, Ming Hui; Chang, Ming-Min; Tyan, Yu Chang; Chen, Yi Ming Arthur.

In: Toxicology and Applied Pharmacology, Vol. 378, 114607, 01.09.2019.

Research output: Contribution to journalReview article

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T1 - Tumor suppressor gene glycine N-methyltransferase and its potential in liver disorders and hepatocellular carcinoma

AU - Chen, Marcelo

AU - Yang, Ming Hui

AU - Chang, Ming-Min

AU - Tyan, Yu Chang

AU - Chen, Yi Ming Arthur

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