Tuning the Distance of Rattle-Shaped IONP@Shell-in-Shell Nanoparticles for Magnetically-Targeted Photothermal Therapy in the Second Near-Infrared Window

Ming Fong Tsai, Chin Hsu, Chen-Sheng Yeh, Yu Jen Hsiao, Chia Hao Su, Li Fang Wang

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Construction of multifunctional nanoparticles (NPs) with near-infrared (NIR) plasmonic responses is considered a versatile and multifaceted platform for several biomedical applications. Herein, a double layer of Au/Ag alloy on the surface of truncated octahedral iron oxide NPs (IONPs) was prepared and the distance between the layers was controlled to exhibit broad and strong NIR absorption. The rattle-shaped IONP@shell-in-shell nanostructure showed light-response to the NIR biological window from 650 to 1300 nm for photothermal therapy (PTT) and magnetic guidance for hyperthermia and magnetic resonance imaging (MRI) diagnosis. Exposing the aqueous solution of IONP@shell-in-shell to a 1064 nm diode laser, its heat conversion efficiency was ∼28.3%. The in vitro cell viability at a gold concentration of 100 ppm was ∼85%, and decreased to ∼16% when the cells were treated with the NIR irradiation and magnetic attraction. T2-weighted MRI images showed a clear accumulation of IONP@shell-in-shell at the tumor site with magnetic attraction. In vivo luminescence tumor images explained that the IONP@shell-in-shell could reduce the U87MG-luc2 cancer cell proliferation in mice with the NIR irradiation and magnetic attraction. These results indicate the IONP@shell-in-shell as a promising nanomedicine for PTT, magnetic targeting, and magnetic resonance imaging (MRI).

Original languageEnglish
Pages (from-to)1508-1519
Number of pages12
JournalACS Applied Materials and Interfaces
Volume10
Issue number2
DOIs
Publication statusPublished - 2018 Jan 17

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Iron oxides
Tuning
Nanoparticles
Infrared radiation
Magnetic resonance
Imaging techniques
Tumors
Irradiation
Medical nanotechnology
Cell proliferation
Infrared absorption
Gold
Conversion efficiency
Semiconductor lasers
ferric oxide
Luminescence
Nanostructures
Cells

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

Cite this

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title = "Tuning the Distance of Rattle-Shaped IONP@Shell-in-Shell Nanoparticles for Magnetically-Targeted Photothermal Therapy in the Second Near-Infrared Window",
abstract = "Construction of multifunctional nanoparticles (NPs) with near-infrared (NIR) plasmonic responses is considered a versatile and multifaceted platform for several biomedical applications. Herein, a double layer of Au/Ag alloy on the surface of truncated octahedral iron oxide NPs (IONPs) was prepared and the distance between the layers was controlled to exhibit broad and strong NIR absorption. The rattle-shaped IONP@shell-in-shell nanostructure showed light-response to the NIR biological window from 650 to 1300 nm for photothermal therapy (PTT) and magnetic guidance for hyperthermia and magnetic resonance imaging (MRI) diagnosis. Exposing the aqueous solution of IONP@shell-in-shell to a 1064 nm diode laser, its heat conversion efficiency was ∼28.3{\%}. The in vitro cell viability at a gold concentration of 100 ppm was ∼85{\%}, and decreased to ∼16{\%} when the cells were treated with the NIR irradiation and magnetic attraction. T2-weighted MRI images showed a clear accumulation of IONP@shell-in-shell at the tumor site with magnetic attraction. In vivo luminescence tumor images explained that the IONP@shell-in-shell could reduce the U87MG-luc2 cancer cell proliferation in mice with the NIR irradiation and magnetic attraction. These results indicate the IONP@shell-in-shell as a promising nanomedicine for PTT, magnetic targeting, and magnetic resonance imaging (MRI).",
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Tuning the Distance of Rattle-Shaped IONP@Shell-in-Shell Nanoparticles for Magnetically-Targeted Photothermal Therapy in the Second Near-Infrared Window. / Tsai, Ming Fong; Hsu, Chin; Yeh, Chen-Sheng; Hsiao, Yu Jen; Su, Chia Hao; Wang, Li Fang.

In: ACS Applied Materials and Interfaces, Vol. 10, No. 2, 17.01.2018, p. 1508-1519.

Research output: Contribution to journalArticle

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AU - Hsu, Chin

AU - Yeh, Chen-Sheng

AU - Hsiao, Yu Jen

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AU - Wang, Li Fang

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