Turing patterning with and without a global wave

Masafumi Inaba; Hans I.Chen Harn; Chuong Cheng-Ming

doi:10.1371/journal.pbio.3000195

Turing patterning with and without a global wave

Masafumi Inaba, Hans I.Chen Harn, Chuong Cheng-Ming

International Center for Wound Repair and Regeneration

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Periodic patterning represents a fundamental process in tissue morphogenesis. In chicken dorsal skin, feather formation starts from the midline; then the morphogenetic wave propagates bilaterally, leaving a regular hexagonal array of feather germs. Yet, in vitro reconstitution showed feather germs appear simultaneously, leading to the hypothesis that the feather-forming wave results from the coupling of local Turing patterning processes with an unidentified global event. In this issue, Ho and colleagues showed such a global event in chicken feathers involves a spreading Ectodysplasin A (EDA) wave and Fibroblast Growth Factor 20 (FGF20)-cell aggregate-based mechanochemical coupling. In flightless birds, feather germs form periodically but without precise hexagonal patterning due to the lack of global wave.

Original language	English
Article number	e3000195
Journal	PLoS biology
Volume	17
Issue number	3
DOIs	https://doi.org/10.1371/journal.pbio.3000195
Publication status	Published - 2019 Mar

All Science Journal Classification (ASJC) codes

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
Agricultural and Biological Sciences(all)

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10.1371/journal.pbio.3000195

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title = "Turing patterning with and without a global wave",

abstract = "Periodic patterning represents a fundamental process in tissue morphogenesis. In chicken dorsal skin, feather formation starts from the midline; then the morphogenetic wave propagates bilaterally, leaving a regular hexagonal array of feather germs. Yet, in vitro reconstitution showed feather germs appear simultaneously, leading to the hypothesis that the feather-forming wave results from the coupling of local Turing patterning processes with an unidentified global event. In this issue, Ho and colleagues showed such a global event in chicken feathers involves a spreading Ectodysplasin A (EDA) wave and Fibroblast Growth Factor 20 (FGF20)-cell aggregate-based mechanochemical coupling. In flightless birds, feather germs form periodically but without precise hexagonal patterning due to the lack of global wave.",

author = "Masafumi Inaba and Harn, {Hans I.Chen} and Chuong Cheng-Ming",

note = "Funding Information: M.I. is supported by Human Frontier Science Program (LT001148/2015-L). HIH is supported by grant from Ministry of Education of Taiwan. CMC is supported by NIH Grants AR47364, AR60306, and GM125322. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.",

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AU - Inaba, Masafumi

AU - Harn, Hans I.Chen

AU - Cheng-Ming, Chuong

N1 - Funding Information: M.I. is supported by Human Frontier Science Program (LT001148/2015-L). HIH is supported by grant from Ministry of Education of Taiwan. CMC is supported by NIH Grants AR47364, AR60306, and GM125322. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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