Abstract
Periodic patterning represents a fundamental process in tissue morphogenesis. In chicken dorsal skin, feather formation starts from the midline; then the morphogenetic wave propagates bilaterally, leaving a regular hexagonal array of feather germs. Yet, in vitro reconstitution showed feather germs appear simultaneously, leading to the hypothesis that the feather-forming wave results from the coupling of local Turing patterning processes with an unidentified global event. In this issue, Ho and colleagues showed such a global event in chicken feathers involves a spreading Ectodysplasin A (EDA) wave and Fibroblast Growth Factor 20 (FGF20)-cell aggregate-based mechanochemical coupling. In flightless birds, feather germs form periodically but without precise hexagonal patterning due to the lack of global wave.
| Original language | English |
|---|---|
| Article number | e3000195 |
| Journal | PLoS biology |
| Volume | 17 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2019 Mar |
Fingerprint
All Science Journal Classification (ASJC) codes
- Neuroscience(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)
- Agricultural and Biological Sciences(all)
Cite this
}
Turing patterning with and without a global wave. / Inaba, Masafumi; Harn, Hans I.Chen; Cheng-Ming, Chuong.
In: PLoS biology, Vol. 17, No. 3, e3000195, 03.2019.Research output: Contribution to journal › Article
TY - JOUR
T1 - Turing patterning with and without a global wave
AU - Inaba, Masafumi
AU - Harn, Hans I.Chen
AU - Cheng-Ming, Chuong
PY - 2019/3
Y1 - 2019/3
N2 - Periodic patterning represents a fundamental process in tissue morphogenesis. In chicken dorsal skin, feather formation starts from the midline; then the morphogenetic wave propagates bilaterally, leaving a regular hexagonal array of feather germs. Yet, in vitro reconstitution showed feather germs appear simultaneously, leading to the hypothesis that the feather-forming wave results from the coupling of local Turing patterning processes with an unidentified global event. In this issue, Ho and colleagues showed such a global event in chicken feathers involves a spreading Ectodysplasin A (EDA) wave and Fibroblast Growth Factor 20 (FGF20)-cell aggregate-based mechanochemical coupling. In flightless birds, feather germs form periodically but without precise hexagonal patterning due to the lack of global wave.
AB - Periodic patterning represents a fundamental process in tissue morphogenesis. In chicken dorsal skin, feather formation starts from the midline; then the morphogenetic wave propagates bilaterally, leaving a regular hexagonal array of feather germs. Yet, in vitro reconstitution showed feather germs appear simultaneously, leading to the hypothesis that the feather-forming wave results from the coupling of local Turing patterning processes with an unidentified global event. In this issue, Ho and colleagues showed such a global event in chicken feathers involves a spreading Ectodysplasin A (EDA) wave and Fibroblast Growth Factor 20 (FGF20)-cell aggregate-based mechanochemical coupling. In flightless birds, feather germs form periodically but without precise hexagonal patterning due to the lack of global wave.
UR - http://www.scopus.com/inward/record.url?scp=85064038880&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064038880&partnerID=8YFLogxK
U2 - 10.1371/journal.pbio.3000195
DO - 10.1371/journal.pbio.3000195
M3 - Article
C2 - 30908496
AN - SCOPUS:85064038880
VL - 17
JO - PLoS Biology
JF - PLoS Biology
SN - 1544-9173
IS - 3
M1 - e3000195
ER -