TY - JOUR
T1 - Turing patterning with and without a global wave
AU - Inaba, Masafumi
AU - Harn, Hans I.Chen
AU - Cheng-Ming, Chuong
N1 - Funding Information:
M.I. is supported by Human Frontier Science Program (LT001148/2015-L). HIH is supported by grant from Ministry of Education of Taiwan. CMC is supported by NIH Grants AR47364, AR60306, and GM125322. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Publisher Copyright:
© 2019 Inaba et al.
PY - 2019/3
Y1 - 2019/3
N2 - Periodic patterning represents a fundamental process in tissue morphogenesis. In chicken dorsal skin, feather formation starts from the midline; then the morphogenetic wave propagates bilaterally, leaving a regular hexagonal array of feather germs. Yet, in vitro reconstitution showed feather germs appear simultaneously, leading to the hypothesis that the feather-forming wave results from the coupling of local Turing patterning processes with an unidentified global event. In this issue, Ho and colleagues showed such a global event in chicken feathers involves a spreading Ectodysplasin A (EDA) wave and Fibroblast Growth Factor 20 (FGF20)-cell aggregate-based mechanochemical coupling. In flightless birds, feather germs form periodically but without precise hexagonal patterning due to the lack of global wave.
AB - Periodic patterning represents a fundamental process in tissue morphogenesis. In chicken dorsal skin, feather formation starts from the midline; then the morphogenetic wave propagates bilaterally, leaving a regular hexagonal array of feather germs. Yet, in vitro reconstitution showed feather germs appear simultaneously, leading to the hypothesis that the feather-forming wave results from the coupling of local Turing patterning processes with an unidentified global event. In this issue, Ho and colleagues showed such a global event in chicken feathers involves a spreading Ectodysplasin A (EDA) wave and Fibroblast Growth Factor 20 (FGF20)-cell aggregate-based mechanochemical coupling. In flightless birds, feather germs form periodically but without precise hexagonal patterning due to the lack of global wave.
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U2 - 10.1371/journal.pbio.3000195
DO - 10.1371/journal.pbio.3000195
M3 - Article
C2 - 30908496
AN - SCOPUS:85064038880
VL - 17
JO - PLoS Biology
JF - PLoS Biology
SN - 1544-9173
IS - 3
M1 - e3000195
ER -