Turing patterning with and without a global wave

Masafumi Inaba, Hans I.Chen Harn, Chuong Cheng-Ming

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Periodic patterning represents a fundamental process in tissue morphogenesis. In chicken dorsal skin, feather formation starts from the midline; then the morphogenetic wave propagates bilaterally, leaving a regular hexagonal array of feather germs. Yet, in vitro reconstitution showed feather germs appear simultaneously, leading to the hypothesis that the feather-forming wave results from the coupling of local Turing patterning processes with an unidentified global event. In this issue, Ho and colleagues showed such a global event in chicken feathers involves a spreading Ectodysplasin A (EDA) wave and Fibroblast Growth Factor 20 (FGF20)-cell aggregate-based mechanochemical coupling. In flightless birds, feather germs form periodically but without precise hexagonal patterning due to the lack of global wave.

Original languageEnglish
Article numbere3000195
JournalPLoS biology
Volume17
Issue number3
DOIs
Publication statusPublished - 2019 Mar

Fingerprint

Feathers
feathers
Ectodysplasins
Fibroblast Growth Factors
Chickens
Birds
chicken skin
fibroblast growth factors
Skin
Tissue
cell aggregates
Morphogenesis
morphogenesis
chickens
birds

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Inaba, Masafumi ; Harn, Hans I.Chen ; Cheng-Ming, Chuong. / Turing patterning with and without a global wave. In: PLoS biology. 2019 ; Vol. 17, No. 3.
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Turing patterning with and without a global wave. / Inaba, Masafumi; Harn, Hans I.Chen; Cheng-Ming, Chuong.

In: PLoS biology, Vol. 17, No. 3, e3000195, 03.2019.

Research output: Contribution to journalArticle

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