Two case studies of hypothermia induced by an increased dosage of zotepine in a combination therapy

Kao Ching Chen; Yen Kuang Yang; Po See Chen; Tzung Lieh Yeh; Ming Jen Yang

doi:10.1046/j.1440-1819.2003.01133.x

Two case studies of hypothermia induced by an increased dosage of zotepine in a combination therapy

Kao Ching Chen, Yen Kuang Yang, Po See Chen, Tzung Lieh Yeh, Ming Jen Yang

Department of Psychiatry

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The purpose of the present paper was to remind physicians that hypothermia is a possible side-effect of combining zotepine, valproate, and benzodiazepine. Two cases of hypothermia occurred after combining the use of zotepine, valproate, and benzodiazepine. The valproate was under therapeutic blood level when zotepine dosage was raised to 200 mg/day, and hypothermia occurred. The dosage of zotepine might constitute a positive correlation with hypothermia. The combination of zotepine, valproate or benzodiazepine may cause hypothermia as a side-effect.

Original language	English
Pages (from-to)	369-371
Number of pages	3
Journal	Psychiatry and Clinical Neurosciences
Volume	57
Issue number	4
DOIs	https://doi.org/10.1046/j.1440-1819.2003.01133.x
Publication status	Published - 2003 Aug

All Science Journal Classification (ASJC) codes

Neuroscience(all)
Neurology
Clinical Neurology
Psychiatry and Mental health

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title = "Two case studies of hypothermia induced by an increased dosage of zotepine in a combination therapy",

abstract = "The purpose of the present paper was to remind physicians that hypothermia is a possible side-effect of combining zotepine, valproate, and benzodiazepine. Two cases of hypothermia occurred after combining the use of zotepine, valproate, and benzodiazepine. The valproate was under therapeutic blood level when zotepine dosage was raised to 200 mg/day, and hypothermia occurred. The dosage of zotepine might constitute a positive correlation with hypothermia. The combination of zotepine, valproate or benzodiazepine may cause hypothermia as a side-effect.",

author = "Chen, {Kao Ching} and Yang, {Yen Kuang} and Chen, {Po See} and Yeh, {Tzung Lieh} and Yang, {Ming Jen}",

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AU - Chen, Kao Ching

AU - Yang, Yen Kuang

AU - Chen, Po See

AU - Yeh, Tzung Lieh

AU - Yang, Ming Jen

PY - 2003/8

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AB - The purpose of the present paper was to remind physicians that hypothermia is a possible side-effect of combining zotepine, valproate, and benzodiazepine. Two cases of hypothermia occurred after combining the use of zotepine, valproate, and benzodiazepine. The valproate was under therapeutic blood level when zotepine dosage was raised to 200 mg/day, and hypothermia occurred. The dosage of zotepine might constitute a positive correlation with hypothermia. The combination of zotepine, valproate or benzodiazepine may cause hypothermia as a side-effect.

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