Two-Photon Photoexcited Photodynamic Therapy and Contrast Agent with Antimicrobial Graphene Quantum Dots

Wen Shuo Kuo, Chia Yuan Chang, Hua Han Chen, Chih Li Lilian Hsu, Jiu Yao Wang, Hui Fang Kao, Lawrence Chao Shan Chou, Yi Chun Chen, Shean Jen Chen, Wen Tsan Chang, Shih Wen Tseng, Ping Ching Wu, Ying Chih Pu

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)

Abstract

A graphene quantum dot (GQD) used as the photosensitizer with high two-photon absorption in the near-infrared region, a large absolute cross section of two-photon excitation (TPE), strong two-photon luminescence, and impressive two-photon stability could be used for dual modality two-photon photodynamic therapy (PDT) and two-photon bioimaging with an ultrashot pulse laser (or defined as TPE). In this study, a GQD efficiently generated reactive oxygen species coupled with TPE, which highly increased the effective PDT ability of both Gram-positive and -negative bacteria, with ultralow energy and an extremely short photoexcitation time generated by TPE. Because of its two-photon properties, a GQD could serve as a promising two-photon contrast agent for observing specimens in depth in three-dimensional biological environments while simultaneously proceeding with PDT action to eliminate bacteria, particularly in multidrug-resistant (MDR) strains. This procedure would provide an efficient alternative approach to easily cope with MDR bacteria.

Original languageEnglish
Pages (from-to)30467-30474
Number of pages8
JournalACS Applied Materials and Interfaces
Volume8
Issue number44
DOIs
Publication statusPublished - 2016 Nov 9

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

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