Two-Photon Photoexcited Photodynamic Therapy and Contrast Agent with Antimicrobial Graphene Quantum Dots

Wen Shuo Kuo, Chia-Yuan Chang, Hua Han Chen, Chih-Li Hsu, Jiu-Yao Wang, Hui Fang Kao, Lawrence Chao Shan Chou, Yi-Chun Chen, Shean Jen Chen, Wen-Tsan Chang, Shih Wen Tseng, Ping-Ching Wu, Ying Chih Pu

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

A graphene quantum dot (GQD) used as the photosensitizer with high two-photon absorption in the near-infrared region, a large absolute cross section of two-photon excitation (TPE), strong two-photon luminescence, and impressive two-photon stability could be used for dual modality two-photon photodynamic therapy (PDT) and two-photon bioimaging with an ultrashot pulse laser (or defined as TPE). In this study, a GQD efficiently generated reactive oxygen species coupled with TPE, which highly increased the effective PDT ability of both Gram-positive and -negative bacteria, with ultralow energy and an extremely short photoexcitation time generated by TPE. Because of its two-photon properties, a GQD could serve as a promising two-photon contrast agent for observing specimens in depth in three-dimensional biological environments while simultaneously proceeding with PDT action to eliminate bacteria, particularly in multidrug-resistant (MDR) strains. This procedure would provide an efficient alternative approach to easily cope with MDR bacteria.

Original languageEnglish
Pages (from-to)30467-30474
Number of pages8
JournalACS Applied Materials and Interfaces
Volume8
Issue number44
DOIs
Publication statusPublished - 2016 Nov 9

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Photodynamic therapy
Graphite
Graphene
Contrast Media
Semiconductor quantum dots
Photons
Bacteria
Photosensitizing Agents
Photosensitizers
Photoexcitation
Luminescence
Laser pulses
Reactive Oxygen Species
Infrared radiation

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

Cite this

Kuo, Wen Shuo ; Chang, Chia-Yuan ; Chen, Hua Han ; Hsu, Chih-Li ; Wang, Jiu-Yao ; Kao, Hui Fang ; Chou, Lawrence Chao Shan ; Chen, Yi-Chun ; Chen, Shean Jen ; Chang, Wen-Tsan ; Tseng, Shih Wen ; Wu, Ping-Ching ; Pu, Ying Chih. / Two-Photon Photoexcited Photodynamic Therapy and Contrast Agent with Antimicrobial Graphene Quantum Dots. In: ACS Applied Materials and Interfaces. 2016 ; Vol. 8, No. 44. pp. 30467-30474.
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abstract = "A graphene quantum dot (GQD) used as the photosensitizer with high two-photon absorption in the near-infrared region, a large absolute cross section of two-photon excitation (TPE), strong two-photon luminescence, and impressive two-photon stability could be used for dual modality two-photon photodynamic therapy (PDT) and two-photon bioimaging with an ultrashot pulse laser (or defined as TPE). In this study, a GQD efficiently generated reactive oxygen species coupled with TPE, which highly increased the effective PDT ability of both Gram-positive and -negative bacteria, with ultralow energy and an extremely short photoexcitation time generated by TPE. Because of its two-photon properties, a GQD could serve as a promising two-photon contrast agent for observing specimens in depth in three-dimensional biological environments while simultaneously proceeding with PDT action to eliminate bacteria, particularly in multidrug-resistant (MDR) strains. This procedure would provide an efficient alternative approach to easily cope with MDR bacteria.",
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Two-Photon Photoexcited Photodynamic Therapy and Contrast Agent with Antimicrobial Graphene Quantum Dots. / Kuo, Wen Shuo; Chang, Chia-Yuan; Chen, Hua Han; Hsu, Chih-Li; Wang, Jiu-Yao; Kao, Hui Fang; Chou, Lawrence Chao Shan; Chen, Yi-Chun; Chen, Shean Jen; Chang, Wen-Tsan; Tseng, Shih Wen; Wu, Ping-Ching; Pu, Ying Chih.

In: ACS Applied Materials and Interfaces, Vol. 8, No. 44, 09.11.2016, p. 30467-30474.

Research output: Contribution to journalArticle

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AU - Wang, Jiu-Yao

AU - Kao, Hui Fang

AU - Chou, Lawrence Chao Shan

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AU - Chen, Shean Jen

AU - Chang, Wen-Tsan

AU - Tseng, Shih Wen

AU - Wu, Ping-Ching

AU - Pu, Ying Chih

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