Typhoid fever complicated by multiple organ involvement: Report of two cases

Guan Cheng Huang, Chia-Ming Chang, Wen-Chien Ko, Yu Lun Huang, Yin Ching Chuang

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Typhoid fever complicated by multiple organ involvement has been rarely mentioned in the literature. We reported two cases of typhoid fever with several unusual manifestations, including acute renal failure, acute hepatitis, acute pancreatitis, disseminated intravascular coagulation, and lower gastrointestinal bleeding. A renal biopsy in the first case showed no pathological change. Bone marrow biopsy showed focal necrosis of matrix, which might have been due to severe illness. A liver biopsy in the second case showed a predominantly histiocytic proliferation with occasional neutrophilic infiltration in the portal areas and hepatic sinusoids. Focal necrosis, bile duct injury, and multiple eosinophilic bodies were also noted. After appropriate antimicrobial therapy, both patients recovered without any sequelae. The potential of multiple organ involvement is highlighted in typhoid fever, which, on rare occasions, may occur simultaneously in the same patient.

Original languageEnglish
JournalJournal of Infection
Volume51
Issue number2
DOIs
Publication statusPublished - 2005 Aug 1

Fingerprint

Typhoid Fever
Biopsy
Necrosis
Disseminated Intravascular Coagulation
Multiple Trauma
Liver
Bile Ducts
Acute Kidney Injury
Pancreatitis
Hepatitis
Bone Marrow
Hemorrhage
Kidney
Therapeutics

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

@article{581a084260b448b79ae36f1903a32a96,
title = "Typhoid fever complicated by multiple organ involvement: Report of two cases",
abstract = "Typhoid fever complicated by multiple organ involvement has been rarely mentioned in the literature. We reported two cases of typhoid fever with several unusual manifestations, including acute renal failure, acute hepatitis, acute pancreatitis, disseminated intravascular coagulation, and lower gastrointestinal bleeding. A renal biopsy in the first case showed no pathological change. Bone marrow biopsy showed focal necrosis of matrix, which might have been due to severe illness. A liver biopsy in the second case showed a predominantly histiocytic proliferation with occasional neutrophilic infiltration in the portal areas and hepatic sinusoids. Focal necrosis, bile duct injury, and multiple eosinophilic bodies were also noted. After appropriate antimicrobial therapy, both patients recovered without any sequelae. The potential of multiple organ involvement is highlighted in typhoid fever, which, on rare occasions, may occur simultaneously in the same patient.",
author = "Huang, {Guan Cheng} and Chia-Ming Chang and Wen-Chien Ko and Huang, {Yu Lun} and Chuang, {Yin Ching}",
year = "2005",
month = "8",
day = "1",
doi = "10.1016/j.jinf.2004.08.018",
language = "English",
volume = "51",
journal = "Journal of Infection",
issn = "0163-4453",
publisher = "W.B. Saunders Ltd",
number = "2",

}

Typhoid fever complicated by multiple organ involvement : Report of two cases. / Huang, Guan Cheng; Chang, Chia-Ming; Ko, Wen-Chien; Huang, Yu Lun; Chuang, Yin Ching.

In: Journal of Infection, Vol. 51, No. 2, 01.08.2005.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Typhoid fever complicated by multiple organ involvement

T2 - Report of two cases

AU - Huang, Guan Cheng

AU - Chang, Chia-Ming

AU - Ko, Wen-Chien

AU - Huang, Yu Lun

AU - Chuang, Yin Ching

PY - 2005/8/1

Y1 - 2005/8/1

N2 - Typhoid fever complicated by multiple organ involvement has been rarely mentioned in the literature. We reported two cases of typhoid fever with several unusual manifestations, including acute renal failure, acute hepatitis, acute pancreatitis, disseminated intravascular coagulation, and lower gastrointestinal bleeding. A renal biopsy in the first case showed no pathological change. Bone marrow biopsy showed focal necrosis of matrix, which might have been due to severe illness. A liver biopsy in the second case showed a predominantly histiocytic proliferation with occasional neutrophilic infiltration in the portal areas and hepatic sinusoids. Focal necrosis, bile duct injury, and multiple eosinophilic bodies were also noted. After appropriate antimicrobial therapy, both patients recovered without any sequelae. The potential of multiple organ involvement is highlighted in typhoid fever, which, on rare occasions, may occur simultaneously in the same patient.

AB - Typhoid fever complicated by multiple organ involvement has been rarely mentioned in the literature. We reported two cases of typhoid fever with several unusual manifestations, including acute renal failure, acute hepatitis, acute pancreatitis, disseminated intravascular coagulation, and lower gastrointestinal bleeding. A renal biopsy in the first case showed no pathological change. Bone marrow biopsy showed focal necrosis of matrix, which might have been due to severe illness. A liver biopsy in the second case showed a predominantly histiocytic proliferation with occasional neutrophilic infiltration in the portal areas and hepatic sinusoids. Focal necrosis, bile duct injury, and multiple eosinophilic bodies were also noted. After appropriate antimicrobial therapy, both patients recovered without any sequelae. The potential of multiple organ involvement is highlighted in typhoid fever, which, on rare occasions, may occur simultaneously in the same patient.

UR - http://www.scopus.com/inward/record.url?scp=22144465171&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22144465171&partnerID=8YFLogxK

U2 - 10.1016/j.jinf.2004.08.018

DO - 10.1016/j.jinf.2004.08.018

M3 - Article

C2 - 16038753

AN - SCOPUS:22144465171

VL - 51

JO - Journal of Infection

JF - Journal of Infection

SN - 0163-4453

IS - 2

ER -