Ultrasonography for Diagnosing Carpal Tunnel Syndrome: A Meta-Analysis of Diagnostic Test Accuracy

Ta Wei Tai, Cheng Yi Wu, Fong Chin Su, Tai Chang Chern, I. Ming Jou

Research output: Contribution to journalArticlepeer-review

110 Citations (Scopus)


Ultrasonography is widely used to diagnose carpal tunnel syndrome (CTS), a common peripheral neuropathy, but the reported diagnostic accuracy varies. This meta-analysis focused on the diagnostic test accuracy of ultrasonography for diagnosing CTS. Structured searches of PubMed for 1990-2010 were done and the data were extracted and meta-analyzed by pooling estimates of sensitivity, specificity, likelihood ratios and diagnostic odds ratios. Diagnostic performance was also judged by using a summary receiver operating characteristic curve. Twenty-eight trials involving 3995 wrists were included. A greater cross-sectional area (CSA) of the median nerve at the carpal tunnel inlet (CSA-I) and a greater flattening ratio at the level of the hamate were seen in CTS wrists than in control wrists. A CSA-I ≥9 mm 2 is the best single diagnostic criterion, with a diagnostic odds ratio of 40.4 (sensitivity 87.3%, specificity 83.3%).

Original languageEnglish
Pages (from-to)1121-1128
Number of pages8
JournalUltrasound in Medicine and Biology
Issue number7
Publication statusPublished - 2012 Jul

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology
  • Biophysics
  • Acoustics and Ultrasonics


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