Ultrasound-activated nanomaterials for sonodynamic cancer theranostics

Nan Wu, Ching Hsiang Fan, Chih Kuang Yeh

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

Despite intensive efforts to develop diagnostic and therapeutic tools, the successful treatment of cancer is still hampered by the obscure boundary between cancerous cells and normal cells, recurrence of the cancer, and the development of drug resistance during chemotherapy. In recent years, sonodynamic therapy (SDT), employing therapeutic ultrasound with sonosensitizers, has attracted attention as a potentially promising approach for cancer therapy. This review describes the current understanding of the mechanisms and the preclinical and clinical efficacy of SDT-based applications in tumors, providing an insight into the therapeutic potential offered by SDT. The limitations and future directions of this emerging treatment are also discussed.

Original languageEnglish
Pages (from-to)1590-1603
Number of pages14
JournalDrug Discovery Today
Volume27
Issue number6
DOIs
Publication statusPublished - 2022 Jun

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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