Ultrasound-chemical hybrid system for manipulating cellular activities

Ching Hsiang Fan, Yao Shen Huang, Yu Chun Lin, Chih Kuang Yeh

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Focused ultrasound (FUS) with microbubbles (MBs) can enhance delivery of impermeable materials into cells for eliminating abnormal cells or enhancing gene transfection. Very few of the existing systems can precisely control cellular physiology. Chemically-inducible dimerization (CID) system has already gained widespread popularity as a tool in cell biology and has been used to address the diverse, yet fundamental biological questions. Although remotely triggering CID system by external stimuli such as light has been developed, it is still challenging to deliver light to the tissues deeper than just 2 mm without any invasive surgical procedures. This study proposed a new ultrasound-chemical hybrid system to trigger the CID system by FUS with MBs. With FUS, membrane impermeable chemical dimerizers can be introduced into cells to spatiotemporally control cellular physiology within timescale of minutes.

Original languageEnglish
Title of host publication2017 IEEE International Ultrasonics Symposium, IUS 2017
PublisherIEEE Computer Society
ISBN (Electronic)9781538633830
DOIs
Publication statusPublished - 2017 Oct 31
Event2017 IEEE International Ultrasonics Symposium, IUS 2017 - Washington, United States
Duration: 2017 Sep 62017 Sep 9

Publication series

NameIEEE International Ultrasonics Symposium, IUS
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Other

Other2017 IEEE International Ultrasonics Symposium, IUS 2017
CountryUnited States
CityWashington
Period17-09-0617-09-09

All Science Journal Classification (ASJC) codes

  • Acoustics and Ultrasonics

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