Uncertainty in cancer risk at low doses of inorganic arsenic

Kenneth G. Brown, How Ran Guo, Howard L. Greene

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


It is unknown whether inorganic arsenic in drinking water concentrations at the current maximum contaminant level of 50 μg/l poses a cancer risk in the United States. Data from two large epidemiological studies of cancer and arsenic in drinking water in Taiwan indicate a dose-response relationship, but the magnitude of risk at low concentrations is highly uncertain. Four sources of uncertainty are described: model choice, data aggregation, intra-village variability of arsenic in well water, arsenic intake from food. New data from an appropriately designed epidemiological study are needed to improve dose-response assessment.

Original languageEnglish
Pages (from-to)351-362
Number of pages12
JournalHuman and Ecological Risk Assessment (HERA)
Issue number3
Publication statusPublished - 1997

All Science Journal Classification (ASJC) codes

  • Ecological Modelling
  • Pollution
  • Health, Toxicology and Mutagenesis


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