Uncertainty in cancer risk at low doses of inorganic arsenic

Kenneth G. Brown; How Ran Guo; Howard L. Greene

doi:10.1080/10807039709383693

Uncertainty in cancer risk at low doses of inorganic arsenic

Kenneth G. Brown, How Ran Guo, Howard L. Greene

Department of Environmental and Occupational Health

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

It is unknown whether inorganic arsenic in drinking water concentrations at the current maximum contaminant level of 50 μg/l poses a cancer risk in the United States. Data from two large epidemiological studies of cancer and arsenic in drinking water in Taiwan indicate a dose-response relationship, but the magnitude of risk at low concentrations is highly uncertain. Four sources of uncertainty are described: model choice, data aggregation, intra-village variability of arsenic in well water, arsenic intake from food. New data from an appropriately designed epidemiological study are needed to improve dose-response assessment.

Original language	English
Pages (from-to)	351-362
Number of pages	12
Journal	Human and Ecological Risk Assessment (HERA)
Volume	3
Issue number	3
DOIs	https://doi.org/10.1080/10807039709383693
Publication status	Published - 1997

All Science Journal Classification (ASJC) codes

Ecological Modelling
Pollution
Health, Toxicology and Mutagenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/10807039709383693

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AB - It is unknown whether inorganic arsenic in drinking water concentrations at the current maximum contaminant level of 50 μg/l poses a cancer risk in the United States. Data from two large epidemiological studies of cancer and arsenic in drinking water in Taiwan indicate a dose-response relationship, but the magnitude of risk at low concentrations is highly uncertain. Four sources of uncertainty are described: model choice, data aggregation, intra-village variability of arsenic in well water, arsenic intake from food. New data from an appropriately designed epidemiological study are needed to improve dose-response assessment.

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Uncertainty in cancer risk at low doses of inorganic arsenic

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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