Unravelling the neuropathogenesis of Japanese encephalitis

Khin Saw Aye Myint, Robert V. Gibbons, Guey Chuen Perng, Tom Solomon

Research output: Contribution to journalReview articlepeer-review

15 Citations (Scopus)

Abstract

Japanese encephalitis is a devastating disease that causes a frequently fatal encephalitis and is a major health problem throughout much of Asia. Mortality rates can be as high as 30%, with one-third of survivors suffering severe neurological sequelae. Viral cytopathology is important, but the contribution of blood-brain barrier breakdown, the inflammatory response and bystander cell death are unknown. Studies that address the mechanisms producing neuronal dysfunction and damage are required, including the examination of autopsy tissues. A better understanding of these mechanisms may lead to therapeutic strategies to reduce brain injury and neurological sequelae.

Original languageEnglish
Pages (from-to)955-956
Number of pages2
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume101
Issue number10
DOIs
Publication statusPublished - 2007 Oct 1

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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