Abstract
Japanese encephalitis is a devastating disease that causes a frequently fatal encephalitis and is a major health problem throughout much of Asia. Mortality rates can be as high as 30%, with one-third of survivors suffering severe neurological sequelae. Viral cytopathology is important, but the contribution of blood-brain barrier breakdown, the inflammatory response and bystander cell death are unknown. Studies that address the mechanisms producing neuronal dysfunction and damage are required, including the examination of autopsy tissues. A better understanding of these mechanisms may lead to therapeutic strategies to reduce brain injury and neurological sequelae.
| Original language | English |
|---|---|
| Pages (from-to) | 955-956 |
| Number of pages | 2 |
| Journal | Transactions of the Royal Society of Tropical Medicine and Hygiene |
| Volume | 101 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2007 Oct 1 |
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All Science Journal Classification (ASJC) codes
- Parasitology
- Public Health, Environmental and Occupational Health
- Infectious Diseases
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Unravelling the neuropathogenesis of Japanese encephalitis. / Myint, Khin Saw Aye; Gibbons, Robert V.; Perng, Guey-Chuen; Solomon, Tom.
In: Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 101, No. 10, 01.10.2007, p. 955-956.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Unravelling the neuropathogenesis of Japanese encephalitis
AU - Myint, Khin Saw Aye
AU - Gibbons, Robert V.
AU - Perng, Guey-Chuen
AU - Solomon, Tom
PY - 2007/10/1
Y1 - 2007/10/1
N2 - Japanese encephalitis is a devastating disease that causes a frequently fatal encephalitis and is a major health problem throughout much of Asia. Mortality rates can be as high as 30%, with one-third of survivors suffering severe neurological sequelae. Viral cytopathology is important, but the contribution of blood-brain barrier breakdown, the inflammatory response and bystander cell death are unknown. Studies that address the mechanisms producing neuronal dysfunction and damage are required, including the examination of autopsy tissues. A better understanding of these mechanisms may lead to therapeutic strategies to reduce brain injury and neurological sequelae.
AB - Japanese encephalitis is a devastating disease that causes a frequently fatal encephalitis and is a major health problem throughout much of Asia. Mortality rates can be as high as 30%, with one-third of survivors suffering severe neurological sequelae. Viral cytopathology is important, but the contribution of blood-brain barrier breakdown, the inflammatory response and bystander cell death are unknown. Studies that address the mechanisms producing neuronal dysfunction and damage are required, including the examination of autopsy tissues. A better understanding of these mechanisms may lead to therapeutic strategies to reduce brain injury and neurological sequelae.
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UR - http://www.scopus.com/inward/citedby.url?scp=34548220043&partnerID=8YFLogxK
U2 - 10.1016/j.trstmh.2007.04.004
DO - 10.1016/j.trstmh.2007.04.004
M3 - Review article
C2 - 17544469
AN - SCOPUS:34548220043
VL - 101
SP - 955
EP - 956
JO - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
SN - 0035-9203
IS - 10
ER -