Unravelling the neuropathogenesis of Japanese encephalitis

Khin Saw Aye Myint, Robert V. Gibbons, Guey-Chuen Perng, Tom Solomon

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Japanese encephalitis is a devastating disease that causes a frequently fatal encephalitis and is a major health problem throughout much of Asia. Mortality rates can be as high as 30%, with one-third of survivors suffering severe neurological sequelae. Viral cytopathology is important, but the contribution of blood-brain barrier breakdown, the inflammatory response and bystander cell death are unknown. Studies that address the mechanisms producing neuronal dysfunction and damage are required, including the examination of autopsy tissues. A better understanding of these mechanisms may lead to therapeutic strategies to reduce brain injury and neurological sequelae.

Original languageEnglish
Pages (from-to)955-956
Number of pages2
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume101
Issue number10
DOIs
Publication statusPublished - 2007 Oct 1

Fingerprint

Japanese Encephalitis
Encephalitis
Blood-Brain Barrier
Brain Injuries
Survivors
Autopsy
Cell Death
Mortality
Health
Therapeutics

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Myint, Khin Saw Aye ; Gibbons, Robert V. ; Perng, Guey-Chuen ; Solomon, Tom. / Unravelling the neuropathogenesis of Japanese encephalitis. In: Transactions of the Royal Society of Tropical Medicine and Hygiene. 2007 ; Vol. 101, No. 10. pp. 955-956.
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Unravelling the neuropathogenesis of Japanese encephalitis. / Myint, Khin Saw Aye; Gibbons, Robert V.; Perng, Guey-Chuen; Solomon, Tom.

In: Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 101, No. 10, 01.10.2007, p. 955-956.

Research output: Contribution to journalReview article

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