Abstract
Japanese encephalitis is a devastating disease that causes a frequently fatal encephalitis and is a major health problem throughout much of Asia. Mortality rates can be as high as 30%, with one-third of survivors suffering severe neurological sequelae. Viral cytopathology is important, but the contribution of blood-brain barrier breakdown, the inflammatory response and bystander cell death are unknown. Studies that address the mechanisms producing neuronal dysfunction and damage are required, including the examination of autopsy tissues. A better understanding of these mechanisms may lead to therapeutic strategies to reduce brain injury and neurological sequelae.
Original language | English |
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Pages (from-to) | 955-956 |
Number of pages | 2 |
Journal | Transactions of the Royal Society of Tropical Medicine and Hygiene |
Volume | 101 |
Issue number | 10 |
DOIs | |
Publication status | Published - 2007 Oct 1 |
All Science Journal Classification (ASJC) codes
- Parasitology
- Public Health, Environmental and Occupational Health
- Infectious Diseases