TY - JOUR
T1 - Upconversion Nanodevice-Assisted Healthy Molecular Photocorrection
AU - Kaur, Kamaljit
AU - Bindra, Pulkit
AU - Mondal, Sanjit
AU - Li, Wei Peng
AU - Sharma, Sandeep
AU - Sahu, Bandana Kumari
AU - Naidu, Boddu S.
AU - Yeh, Chen Sheng
AU - Gautam, Ujjal K.
AU - Shanmugam, Vijayakumar
N1 - Publisher Copyright:
©
PY - 2021/1/11
Y1 - 2021/1/11
N2 - Mushrooms are rich in ergosterol, a precursor of ergocalciferol, which is a type of vitamin D2. The conversion of ergosterol to ergocalciferol takes place in the presence of UV radiation by the cleavage of the "B-ring"in the ergosterol. As the UV radiation cannot penetrate deep into the tissue, only minimal increase occurs in sunlight. In this study, upconversion nanoparticles with the property to convert deep-penetrating near-infrared radiation to UV radiation have been cast into a disk to use sunlight and emit UV radiation for vitamin D conversion. An engineered upconversion nanoparticle (UCNP) disk with maximum particles and limited clusters demonstrates ∼2.5 times enhanced vitamin D2 conversion.
AB - Mushrooms are rich in ergosterol, a precursor of ergocalciferol, which is a type of vitamin D2. The conversion of ergosterol to ergocalciferol takes place in the presence of UV radiation by the cleavage of the "B-ring"in the ergosterol. As the UV radiation cannot penetrate deep into the tissue, only minimal increase occurs in sunlight. In this study, upconversion nanoparticles with the property to convert deep-penetrating near-infrared radiation to UV radiation have been cast into a disk to use sunlight and emit UV radiation for vitamin D conversion. An engineered upconversion nanoparticle (UCNP) disk with maximum particles and limited clusters demonstrates ∼2.5 times enhanced vitamin D2 conversion.
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U2 - 10.1021/acsbiomaterials.0c01244
DO - 10.1021/acsbiomaterials.0c01244
M3 - Article
C2 - 33356144
AN - SCOPUS:85099057903
SN - 2373-9878
VL - 7
SP - 291
EP - 298
JO - ACS Biomaterials Science and Engineering
JF - ACS Biomaterials Science and Engineering
IS - 1
ER -