Upconversion Nanodevice-Assisted Healthy Molecular Photocorrection

Kamaljit Kaur, Pulkit Bindra, Sanjit Mondal, Wei Peng Li, Sandeep Sharma, Bandana Kumari Sahu, Boddu S. Naidu, Chen Sheng Yeh, Ujjal K. Gautam, Vijayakumar Shanmugam

Research output: Contribution to journalArticlepeer-review

Abstract

Mushrooms are rich in ergosterol, a precursor of ergocalciferol, which is a type of vitamin D2. The conversion of ergosterol to ergocalciferol takes place in the presence of UV radiation by the cleavage of the "B-ring"in the ergosterol. As the UV radiation cannot penetrate deep into the tissue, only minimal increase occurs in sunlight. In this study, upconversion nanoparticles with the property to convert deep-penetrating near-infrared radiation to UV radiation have been cast into a disk to use sunlight and emit UV radiation for vitamin D conversion. An engineered upconversion nanoparticle (UCNP) disk with maximum particles and limited clusters demonstrates ∼2.5 times enhanced vitamin D2 conversion.

Original languageEnglish
Pages (from-to)291-298
Number of pages8
JournalACS Biomaterials Science and Engineering
Volume7
Issue number1
DOIs
Publication statusPublished - 2021 Jan 11

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering

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