TY - JOUR
T1 - Upconversion Nanodevice-Assisted Healthy Molecular Photocorrection
AU - Kaur, Kamaljit
AU - Bindra, Pulkit
AU - Mondal, Sanjit
AU - Li, Wei Peng
AU - Sharma, Sandeep
AU - Sahu, Bandana Kumari
AU - Naidu, Boddu S.
AU - Yeh, Chen Sheng
AU - Gautam, Ujjal K.
AU - Shanmugam, Vijayakumar
N1 - Funding Information:
V.S. thanks the Department of Science and Technology, Government of India SERB (CRG/2019/006317) and DST Nanomission (SR/NM/NS-1434/2014(G)) for the financial support. The authors are thankful to Dr. Sudesh Kumar, CIAB, Mohali for the ICP analysis, especially in the pandemic time, when other ICP facilities were closed.
Publisher Copyright:
©
PY - 2021/1/11
Y1 - 2021/1/11
N2 - Mushrooms are rich in ergosterol, a precursor of ergocalciferol, which is a type of vitamin D2. The conversion of ergosterol to ergocalciferol takes place in the presence of UV radiation by the cleavage of the "B-ring"in the ergosterol. As the UV radiation cannot penetrate deep into the tissue, only minimal increase occurs in sunlight. In this study, upconversion nanoparticles with the property to convert deep-penetrating near-infrared radiation to UV radiation have been cast into a disk to use sunlight and emit UV radiation for vitamin D conversion. An engineered upconversion nanoparticle (UCNP) disk with maximum particles and limited clusters demonstrates ∼2.5 times enhanced vitamin D2 conversion.
AB - Mushrooms are rich in ergosterol, a precursor of ergocalciferol, which is a type of vitamin D2. The conversion of ergosterol to ergocalciferol takes place in the presence of UV radiation by the cleavage of the "B-ring"in the ergosterol. As the UV radiation cannot penetrate deep into the tissue, only minimal increase occurs in sunlight. In this study, upconversion nanoparticles with the property to convert deep-penetrating near-infrared radiation to UV radiation have been cast into a disk to use sunlight and emit UV radiation for vitamin D conversion. An engineered upconversion nanoparticle (UCNP) disk with maximum particles and limited clusters demonstrates ∼2.5 times enhanced vitamin D2 conversion.
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U2 - 10.1021/acsbiomaterials.0c01244
DO - 10.1021/acsbiomaterials.0c01244
M3 - Article
C2 - 33356144
AN - SCOPUS:85099057903
VL - 7
SP - 291
EP - 298
JO - ACS Biomaterials Science and Engineering
JF - ACS Biomaterials Science and Engineering
SN - 2373-9878
IS - 1
ER -