Uptake and Depuration Kinetics of Pacific Ciguatoxins in Orange-Spotted Grouper (Epinephelus coioides)

Jing Li, Yim Ling Mak, Yu Han Chang, Chengui Xiao, Yi Min Chen, Jincan Shen, Qi Wang, Yuefei Ruan, Paul K.S. Lam

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Ciguatoxins (CTXs), produced by toxic benthic dinoflagellates, can bioaccumulate in marine organisms at higher trophic levels. The current study evaluated the uptake and depuration kinetics of some of the most potent CTXs, Pacific CTX-1, -2, and -3 (P-CTX-1, -2, and -3), in orange-spotted grouper (Epinephelus coioides) exposed to 1 ng P-CTXs g-1 fish daily. Over a 30 d exposure, P-CTX-1, -2, and -3 were consistently detected in various tissues of exposed fish, and the concentrations of the total P-CTXs in tissues generally ranked following the order of liver, intestine, gill, skin, brain, and muscle. Relatively higher uptake rates of P-CTX-1 in the groupers were observed compared with those of P-CTX-2 and -3. The depuration rate constants of P-CTX-1, -2, and -3 in different tissues were (0.996-16.5) × 10-2, (1.51-16.1) × 10-2, and (0.557-10.6) × 10-2 d-1, respectively. The accumulation efficiencies of P-CTX-1, -2, and -3 in whole groupers were 6.13%, 2.61%, and 1.15%, respectively. The increasing proportion of P-CTX-1 and the decreasing proportion of P-CTX-2 and -3 over the exposure phase suggest a likely biotransformation of P-CTX-2 and -3 to P-CTX-1, leading to higher levels of P-CTX-1 in fish and possibly a higher risk of CTXs in long-term exposed fish. copy; 2020 American Chemical Society.

Original languageEnglish
Pages (from-to)4475-4483
Number of pages9
JournalEnvironmental Science and Technology
Volume54
Issue number7
DOIs
Publication statusPublished - 2020 Apr 7

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Environmental Chemistry

Fingerprint Dive into the research topics of 'Uptake and Depuration Kinetics of Pacific Ciguatoxins in Orange-Spotted Grouper (Epinephelus coioides)'. Together they form a unique fingerprint.

Cite this