Urinary 1-hydroxypyrene-glucuronide as a biomarker of exposure to various vehicle exhausts among highway toll-station workers in Taipei, Taiwan

Ching Huang Lai, Saou Hsing Liou, Tung Sheng Shih, Perng Jy Tsai, Hsiao Lung Chen, Timothy J. Buckley, Paul T. Strickland, Jouni J.K. Jaakkola

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

In this cross-sectional study, the authors evaluated urinary 1-hydroxypyrene-glucuronide (1-OHP-gluc) as a potential biomarker of exposure to various traffic exhausts. Subjects were 47 female highway toll-station workers and 27 female office workers in training for toll-station employment in Taipei, Taiwan. The mean concentration of urinary 1-OHP-gluc was 0.117 pmol/mol creatinine in the exposed group and 0.073 μmol/mol creatinine in the reference group (difference in mean concentrations: 0.044 μmol/mol creatinine [95% confidence interval [CI]: 0.015, 0.072). In the lanes where tolls were collected from passenger cars, there was a significant relationship between cumulative traffic and 1-OHP-gluc concentration (i.e., average increase of 0.015 μmol/mol creatinine [95% CI: 0.003, 0.027] per 1,000 vehicles). The average increase for truck/bus lanes was similar to that identified for the car lanes (i.e., average increase of 0.011 μmol/mol creatinine [95% CI: -0.024, 0.045] per 1,000 vehicles). The authors determined that exposure to various traffic exhausts increased the urinary concentration of 1-OHP-gluc in a dose-response pattern, which suggests that this chemical may be a useful biomarker for exposure to vehicle exhausts.

Original languageEnglish
Pages (from-to)61-69
Number of pages9
JournalArchives of Environmental Health
Volume59
Issue number2
DOIs
Publication statusPublished - 2004 Feb 1

All Science Journal Classification (ASJC) codes

  • Environmental Chemistry
  • Environmental Science(all)
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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