TY - JOUR
T1 - Urinary 1-hydroxypyrene-glucuronide as a biomarker of exposure to various vehicle exhausts among highway toll-station workers in Taipei, Taiwan
AU - Lai, Ching Huang
AU - Liou, Saou Hsing
AU - Shih, Tung Sheng
AU - Tsai, Perng Jy
AU - Chen, Hsiao Lung
AU - Buckley, Timothy J.
AU - Strickland, Paul T.
AU - Jaakkola, Jouni J.K.
N1 - Funding Information:
The authors thank the National Science Council, Taiwan, Republic of China, for funding this research project (NSC 89-2314-B-016-116). This study was supported, in part, by U.S. Department of Health and Human Services grants ES03819 and ES06052. Submitted for publication April 25, 2003; revised; accepted for publication June 19, 2003. Requests for reprints should be sent to Dr. Jouni J. K. Jaakkola, Professor and Director of the Institute of Occupational and Environmental Medicine, The University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom. E-mail: j.jaakkola@bham.ac.uk
PY - 2004/2
Y1 - 2004/2
N2 - In this cross-sectional study, the authors evaluated urinary 1-hydroxypyrene-glucuronide (1-OHP-gluc) as a potential biomarker of exposure to various traffic exhausts. Subjects were 47 female highway toll-station workers and 27 female office workers in training for toll-station employment in Taipei, Taiwan. The mean concentration of urinary 1-OHP-gluc was 0.117 pmol/mol creatinine in the exposed group and 0.073 μmol/mol creatinine in the reference group (difference in mean concentrations: 0.044 μmol/mol creatinine [95% confidence interval [CI]: 0.015, 0.072). In the lanes where tolls were collected from passenger cars, there was a significant relationship between cumulative traffic and 1-OHP-gluc concentration (i.e., average increase of 0.015 μmol/mol creatinine [95% CI: 0.003, 0.027] per 1,000 vehicles). The average increase for truck/bus lanes was similar to that identified for the car lanes (i.e., average increase of 0.011 μmol/mol creatinine [95% CI: -0.024, 0.045] per 1,000 vehicles). The authors determined that exposure to various traffic exhausts increased the urinary concentration of 1-OHP-gluc in a dose-response pattern, which suggests that this chemical may be a useful biomarker for exposure to vehicle exhausts.
AB - In this cross-sectional study, the authors evaluated urinary 1-hydroxypyrene-glucuronide (1-OHP-gluc) as a potential biomarker of exposure to various traffic exhausts. Subjects were 47 female highway toll-station workers and 27 female office workers in training for toll-station employment in Taipei, Taiwan. The mean concentration of urinary 1-OHP-gluc was 0.117 pmol/mol creatinine in the exposed group and 0.073 μmol/mol creatinine in the reference group (difference in mean concentrations: 0.044 μmol/mol creatinine [95% confidence interval [CI]: 0.015, 0.072). In the lanes where tolls were collected from passenger cars, there was a significant relationship between cumulative traffic and 1-OHP-gluc concentration (i.e., average increase of 0.015 μmol/mol creatinine [95% CI: 0.003, 0.027] per 1,000 vehicles). The average increase for truck/bus lanes was similar to that identified for the car lanes (i.e., average increase of 0.011 μmol/mol creatinine [95% CI: -0.024, 0.045] per 1,000 vehicles). The authors determined that exposure to various traffic exhausts increased the urinary concentration of 1-OHP-gluc in a dose-response pattern, which suggests that this chemical may be a useful biomarker for exposure to vehicle exhausts.
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U2 - 10.3200/AEOH.59.2.61-69
DO - 10.3200/AEOH.59.2.61-69
M3 - Article
C2 - 16075899
AN - SCOPUS:23044446493
SN - 0003-9896
VL - 59
SP - 61
EP - 69
JO - Archives of Environmental Health
JF - Archives of Environmental Health
IS - 2
ER -
