Urinary Cytokines and Renal Doppler Study in Kawasaki Disease

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: To investigate whether renal vasculitis is the sole cause or merely a contributing cause of renal inflammation in Kawasaki disease (KD). Study design: This prospective study in a university medical center in Taiwan enrolled 24 children with KD between June 2004 and November 2005. All patients underwent a technetium-99 m dimercaptosuccinic acid scintigraphy single-photon emission computed tomography scan, the results of which were used to group the patients with KD as with or without renal involvement. Urine samples underwent a cytokine analysis. Renal Doppler ultrasonography was used to evaluate renal vasculitis by measuring the pulsatility index (PI) and resistance index (RI). Results: Ten of the 24 patients (42%) with renal inflammatory foci were the study group; the remainder composed the control group. Urinary interleukin (IL)-6 levels were significantly higher in the study group (496.7 ± 310.9 vs 115.0 ± 65.9 ng/g urinary creatinine; P < .01), as were PI values (1.85 ± 0.70 vs 1.44 ± 0.53; P < .05). Urinary IL-6 levels and PI values were significantly (P < .05) correlated. Conclusions: Increased urinary IL-6 and elevated renal Doppler measures suggest that immune-mediated vasculitis is one of the mechanisms causing renal inflammation in KD.

Original languageEnglish
Pages (from-to)792-797
Number of pages6
JournalJournal of Pediatrics
Volume156
Issue number5
DOIs
Publication statusPublished - 2010 May 1

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Mucocutaneous Lymph Node Syndrome
Cytokines
Kidney
Vasculitis
Interleukin-6
Succimer
Inflammation
Doppler Ultrasonography
Technetium
Single-Photon Emission-Computed Tomography
Taiwan
Radionuclide Imaging
Creatinine
Urine
Prospective Studies
Control Groups

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

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title = "Urinary Cytokines and Renal Doppler Study in Kawasaki Disease",
abstract = "Objective: To investigate whether renal vasculitis is the sole cause or merely a contributing cause of renal inflammation in Kawasaki disease (KD). Study design: This prospective study in a university medical center in Taiwan enrolled 24 children with KD between June 2004 and November 2005. All patients underwent a technetium-99 m dimercaptosuccinic acid scintigraphy single-photon emission computed tomography scan, the results of which were used to group the patients with KD as with or without renal involvement. Urine samples underwent a cytokine analysis. Renal Doppler ultrasonography was used to evaluate renal vasculitis by measuring the pulsatility index (PI) and resistance index (RI). Results: Ten of the 24 patients (42{\%}) with renal inflammatory foci were the study group; the remainder composed the control group. Urinary interleukin (IL)-6 levels were significantly higher in the study group (496.7 ± 310.9 vs 115.0 ± 65.9 ng/g urinary creatinine; P < .01), as were PI values (1.85 ± 0.70 vs 1.44 ± 0.53; P < .05). Urinary IL-6 levels and PI values were significantly (P < .05) correlated. Conclusions: Increased urinary IL-6 and elevated renal Doppler measures suggest that immune-mediated vasculitis is one of the mechanisms causing renal inflammation in KD.",
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Urinary Cytokines and Renal Doppler Study in Kawasaki Disease. / Wu, Jing-Ming; Chiou, Yuan-Yow; Hung, Wen Pin; Chiu, Nan-Tsing; Chen, Mei Ju; Wang, Jieh-Neng.

In: Journal of Pediatrics, Vol. 156, No. 5, 01.05.2010, p. 792-797.

Research output: Contribution to journalArticle

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