Urine analysis in microfluidic devices

Chun Che Lin, Chin Chung Tseng, Tsung Kai Chuang, Der Seang Lee, Gwo Bin Lee

Research output: Contribution to journalReview article

29 Citations (Scopus)

Abstract

Microfluidics has attracted considerable attention since its early development in the 1980s and has experienced rapid growth in the past three decades due to advantages associated with miniaturization, integration and automation. Urine analysis is a common, fast and inexpensive clinical diagnostic tool in health care. In this article, we will be reviewing recent works starting from 2005 to the present for urine analysis using microfluidic devices or systems and to provide in-depth commentary about these techniques. Moreover, commercial strips that are often treated as chips and their readers for urine analysis will also be briefly discussed. We start with an introduction to the physiological significance of various components or measurement standards in urine analysis, followed by a brief introduction to enabling microfluidic technologies. Then, microfluidic devices or systems for sample pretreatments and for sensing urinary macromolecules, micromolecules, as well as multiplexed analysis are reviewed, in this sequence. Moreover, a microfluidic chip for urinary proteome profiling is also discussed, followed by a section discussing commercial products. Finally, the authors' perspectives on microfluidic-based urine analysis are provided. These advancements in microfluidic techniques for urine analysis may improve current routine clinical practices, particularly for point-of-care (POC) applications.

Original languageEnglish
Pages (from-to)2669-2688
Number of pages20
JournalAnalyst
Volume136
Issue number13
DOIs
Publication statusPublished - 2011 Jul 7

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All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy
  • Electrochemistry

Cite this

Lin, C. C., Tseng, C. C., Chuang, T. K., Lee, D. S., & Lee, G. B. (2011). Urine analysis in microfluidic devices. Analyst, 136(13), 2669-2688. https://doi.org/10.1039/c1an15029d