TY - JOUR
T1 - Urine prothymosin-alpha as novel tumor marker for detection and follow-up of bladder cancer
AU - Tzai, Tzong Shin
AU - Tsai, Yuh Shyan
AU - Shiau, Ai Li
AU - Wu, Chao Liang
AU - Shieh, Gia Shing
AU - Tsai, Hsin Tzu
N1 - Funding Information:
This study was supported by a grant from the National Science Council of Taiwan (NSC 92-2314-B-006-135).
PY - 2006/2
Y1 - 2006/2
N2 - Objectives. To establish the normal range of urine prothymosin-alpha in humans and to investigate its role as a specific tumor marker for the detection and follow-up of transitional cell carcinoma of the urinary bladder before and after curative treatment. Methods. Urine samples were obtained from 151 healthy volunteers, 60 patients with urinary tract infection, 238 patients with bladder transitional cell carcinoma (96 with tumor and 142 tumor free), and 22 patients with non-transitional cell carcinoma tumors. The urine prothymosin-alpha levels were quantified by enzyme-linked immunosorbent assay and then appropriately analyzed and compared among the different study groups. Results. The mean value of urine prothymosin-alpha in healthy volunteers was 0.68 ± 0.13 ng/mL. Regardless of the presence of urinary tract infection, the urine prothymosin-alpha level in patients with newly diagnosed, as yet untreated, bladder cancer was significantly greater than that in those who were tumor free after curative treatment (P = 0.050 and P = 0.026 for the presence and absence of urinary tract infection, respectively). At follow-up, the urine prothymosin-alpha level was constantly elevated when residual or recurrent tumor was present after treatment. Although the urine prothymosin-alpha level in patients with non-transitional cell carcinoma tumors was not significantly different from that of healthy volunteers, it was definitely lower than the level in patients with bladder tumors (P = 0.003). Conclusions. Our findings have revealed that urine prothymosin-alpha has the potential of being a useful tumor marker for the detection and follow-up of bladder cancer.
AB - Objectives. To establish the normal range of urine prothymosin-alpha in humans and to investigate its role as a specific tumor marker for the detection and follow-up of transitional cell carcinoma of the urinary bladder before and after curative treatment. Methods. Urine samples were obtained from 151 healthy volunteers, 60 patients with urinary tract infection, 238 patients with bladder transitional cell carcinoma (96 with tumor and 142 tumor free), and 22 patients with non-transitional cell carcinoma tumors. The urine prothymosin-alpha levels were quantified by enzyme-linked immunosorbent assay and then appropriately analyzed and compared among the different study groups. Results. The mean value of urine prothymosin-alpha in healthy volunteers was 0.68 ± 0.13 ng/mL. Regardless of the presence of urinary tract infection, the urine prothymosin-alpha level in patients with newly diagnosed, as yet untreated, bladder cancer was significantly greater than that in those who were tumor free after curative treatment (P = 0.050 and P = 0.026 for the presence and absence of urinary tract infection, respectively). At follow-up, the urine prothymosin-alpha level was constantly elevated when residual or recurrent tumor was present after treatment. Although the urine prothymosin-alpha level in patients with non-transitional cell carcinoma tumors was not significantly different from that of healthy volunteers, it was definitely lower than the level in patients with bladder tumors (P = 0.003). Conclusions. Our findings have revealed that urine prothymosin-alpha has the potential of being a useful tumor marker for the detection and follow-up of bladder cancer.
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U2 - 10.1016/j.urology.2005.08.034
DO - 10.1016/j.urology.2005.08.034
M3 - Article
C2 - 16461079
AN - SCOPUS:31944447547
SN - 0090-4295
VL - 67
SP - 294
EP - 299
JO - Urology
JF - Urology
IS - 2
ER -