Use of seroprevalence to guide dengue vaccination plans for older adults in a dengue non-endemic country

Yi Hua Pan, Mei Ying Liao, Yu Wen Chien, Tzong Shiann Ho, Hui Ying Ko, Chin Rur Yang, Shu Fen Chang, Chia Yi Yu, Shu Yu Lin, Pin Wei Shih, Pei Yun Shu, Day Yu Chao, Chao Ying Pan, Hong Ming Chen, Guey Chuen Perng, Chia Chi Ku, Chwan Chuen King

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5 Citations (Scopus)


A shift in dengue cases toward the adult population, accompanied by an increased risk of severe cases of dengue in the elderly, has created an important emerging issue in the past decade. To understand the level of past DENV infection among older adults after a large dengue outbreak occurred in southern Taiwan in 2015, we screened 1498 and 2603 serum samples from healthy residents aged ≥ 40 years in Kaohsiung City and Tainan City, respectively, to assess the seroprevalence of anti-DENV IgG in 2016. Seropositive samples were verified to exclude cross-reaction from Japanese encephalitis virus (JEV), using DENV/ JEV-NS1 indirect IgG ELISA. We further identified viral serotypes and secondary DENV infections among positive samples in the two cities. The overall age-standardized seroprevalence of DENV-IgG among participants was 25.77% in Kaohsiung and 11.40% in Tainan, and the seroprevalence was significantly higher in older age groups of both cities. Although the percentages of secondary DENV infection in Kaohsiung and Tainan were very similar (43.09% and 44.76%, respectively), DENV-1 and DENV-2 spanned a wider age range in Kaohsiung, whereas DENV-2 was dominant in Tainan. As very few studies have obtained the serostatus of DENV infection in older adults and the elderly, this study highlights the need for further investigation into antibody status, as well as the safety and efficacy of dengue vaccination in these older populations.

Original languageEnglish
Article numbere0009312
JournalPLoS neglected tropical diseases
Issue number4
Publication statusPublished - 2021 Apr

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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