Use of two intracorporeal ventricular assist devices as a total artificial heart

Muath Bishawi, Jun-Neng Roan, Jordan Richards, Zachary Brown, Laura Blue, Mani A. Daneshmand, Jacob N. Schroder, Dawn E. Bowles, Carmelo A. Milano

Research output: Contribution to journalArticle

Abstract

Mechanical circulatory support (MCS) has been introduced as a viable alternative to heart transplantation primarily through the use of intracorporeal ventricular assist devices (VADs) for support of the left ventricle. However, certain clinical scenarios warrant biventricular mechanical support. One strategy for some patients is the excision of both ventricles and the implantation of two VAD pumps as a total artificial heart (TAH). This has recently been made possible by the improvements in device design and the small profile of centrifugal devices. This TAH approach remains experimental with many important challenges such as the device settings to balance the right and left circulation, the orientation of the devices and the outflow graft with their influence on hemolysis and stability, and the outcome of chronic support using such an orientation. This protocol aims to provide a reproducible approach for total artificial heart replacement with two intracorporeal centrifugal VADs in a cow model.

Original languageEnglish
Article numbere55961
JournalJournal of Visualized Experiments
Volume2018
Issue number135
DOIs
Publication statusPublished - 2018 May 11

Fingerprint

Artificial heart
Artificial Heart
Heart-Assist Devices
Equipment and Supplies
Equipment Design
Heart Transplantation
Hemolysis
Grafts
Heart Ventricles
Pumps
Transplants

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Chemical Engineering(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Bishawi, M., Roan, J-N., Richards, J., Brown, Z., Blue, L., Daneshmand, M. A., ... Milano, C. A. (2018). Use of two intracorporeal ventricular assist devices as a total artificial heart. Journal of Visualized Experiments, 2018(135), [e55961]. https://doi.org/10.3791/55961
Bishawi, Muath ; Roan, Jun-Neng ; Richards, Jordan ; Brown, Zachary ; Blue, Laura ; Daneshmand, Mani A. ; Schroder, Jacob N. ; Bowles, Dawn E. ; Milano, Carmelo A. / Use of two intracorporeal ventricular assist devices as a total artificial heart. In: Journal of Visualized Experiments. 2018 ; Vol. 2018, No. 135.
@article{9ce301fa12564bc4a9a39e985867be0d,
title = "Use of two intracorporeal ventricular assist devices as a total artificial heart",
abstract = "Mechanical circulatory support (MCS) has been introduced as a viable alternative to heart transplantation primarily through the use of intracorporeal ventricular assist devices (VADs) for support of the left ventricle. However, certain clinical scenarios warrant biventricular mechanical support. One strategy for some patients is the excision of both ventricles and the implantation of two VAD pumps as a total artificial heart (TAH). This has recently been made possible by the improvements in device design and the small profile of centrifugal devices. This TAH approach remains experimental with many important challenges such as the device settings to balance the right and left circulation, the orientation of the devices and the outflow graft with their influence on hemolysis and stability, and the outcome of chronic support using such an orientation. This protocol aims to provide a reproducible approach for total artificial heart replacement with two intracorporeal centrifugal VADs in a cow model.",
author = "Muath Bishawi and Jun-Neng Roan and Jordan Richards and Zachary Brown and Laura Blue and Daneshmand, {Mani A.} and Schroder, {Jacob N.} and Bowles, {Dawn E.} and Milano, {Carmelo A.}",
year = "2018",
month = "5",
day = "11",
doi = "10.3791/55961",
language = "English",
volume = "2018",
journal = "Journal of Visualized Experiments",
issn = "1940-087X",
publisher = "MYJoVE Corporation",
number = "135",

}

Bishawi, M, Roan, J-N, Richards, J, Brown, Z, Blue, L, Daneshmand, MA, Schroder, JN, Bowles, DE & Milano, CA 2018, 'Use of two intracorporeal ventricular assist devices as a total artificial heart', Journal of Visualized Experiments, vol. 2018, no. 135, e55961. https://doi.org/10.3791/55961

Use of two intracorporeal ventricular assist devices as a total artificial heart. / Bishawi, Muath; Roan, Jun-Neng; Richards, Jordan; Brown, Zachary; Blue, Laura; Daneshmand, Mani A.; Schroder, Jacob N.; Bowles, Dawn E.; Milano, Carmelo A.

In: Journal of Visualized Experiments, Vol. 2018, No. 135, e55961, 11.05.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Use of two intracorporeal ventricular assist devices as a total artificial heart

AU - Bishawi, Muath

AU - Roan, Jun-Neng

AU - Richards, Jordan

AU - Brown, Zachary

AU - Blue, Laura

AU - Daneshmand, Mani A.

AU - Schroder, Jacob N.

AU - Bowles, Dawn E.

AU - Milano, Carmelo A.

PY - 2018/5/11

Y1 - 2018/5/11

N2 - Mechanical circulatory support (MCS) has been introduced as a viable alternative to heart transplantation primarily through the use of intracorporeal ventricular assist devices (VADs) for support of the left ventricle. However, certain clinical scenarios warrant biventricular mechanical support. One strategy for some patients is the excision of both ventricles and the implantation of two VAD pumps as a total artificial heart (TAH). This has recently been made possible by the improvements in device design and the small profile of centrifugal devices. This TAH approach remains experimental with many important challenges such as the device settings to balance the right and left circulation, the orientation of the devices and the outflow graft with their influence on hemolysis and stability, and the outcome of chronic support using such an orientation. This protocol aims to provide a reproducible approach for total artificial heart replacement with two intracorporeal centrifugal VADs in a cow model.

AB - Mechanical circulatory support (MCS) has been introduced as a viable alternative to heart transplantation primarily through the use of intracorporeal ventricular assist devices (VADs) for support of the left ventricle. However, certain clinical scenarios warrant biventricular mechanical support. One strategy for some patients is the excision of both ventricles and the implantation of two VAD pumps as a total artificial heart (TAH). This has recently been made possible by the improvements in device design and the small profile of centrifugal devices. This TAH approach remains experimental with many important challenges such as the device settings to balance the right and left circulation, the orientation of the devices and the outflow graft with their influence on hemolysis and stability, and the outcome of chronic support using such an orientation. This protocol aims to provide a reproducible approach for total artificial heart replacement with two intracorporeal centrifugal VADs in a cow model.

UR - http://www.scopus.com/inward/record.url?scp=85046684192&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85046684192&partnerID=8YFLogxK

U2 - 10.3791/55961

DO - 10.3791/55961

M3 - Article

VL - 2018

JO - Journal of Visualized Experiments

JF - Journal of Visualized Experiments

SN - 1940-087X

IS - 135

M1 - e55961

ER -