Using a CD-like microfluidic platform for uniform calcium alginate drug carrier generation

Ming Kai Liu, Keng Shiang Huang, Jia Yaw Chang, Chun Han Wu, Yu Cheng Lin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)


In this paper the manipulation of monodisperse Ca-alginate microparticles using a polymer-based CD-like microfluidic platform and a reaction of external gelation is presented. Our strategy was based on associating the rapid injection molding process for cross-junction microchannel with the sheath focusing effect to form uniform water-in-oil (w/o) emulsions. These fine emulsions, consisting of 1.5% w/v Na-alginate, were then dripped into an oil solution containing 20% w/v calcium chloride (CaCl2) to accomplish Ca-alginate microspheres in an efficient manner. We have demonstrated that one can control the size of Ca-alginate microparticles from 20 μm to 50 μm in diameter (with a variation less than 10%) by altering the relative sheath/sample flow rate ratio. Experimental data showed that for a given fixed dispersed phase flow (sample flow), the emulsion size decreased as the average velocity of the continuous phase (oil flow) increased. The proposed CD-like microfluidic platform is capable of generating relatively uniform microdroplets and has the advantages of active control of droplet diameter, simple and low cost process, and high throughput.

Original languageEnglish
Title of host publicationMicrofluidics, BioMEMS, and Medical Microsystems V
Publication statusPublished - 2007 Apr 30
EventMicrofluidics, BioMEMS, and Medical Microsystems V - San Jose, CA, United States
Duration: 2007 Jan 222007 Jan 24

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X


OtherMicrofluidics, BioMEMS, and Medical Microsystems V
Country/TerritoryUnited States
CitySan Jose, CA

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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