Using deep learning to identify translational research in genomic medicine beyond bench to bedside

Yi Yu Hsu, Mindy Clyne, Chih Hsuan Wei, Muin J. Khoury, Zhiyong Lu

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Tracking scientific research publications on the evaluation, utility and implementation of genomic applications is critical for the translation of basic research to impact clinical and population health. In this work, we utilize state-of-the-art machine learning approaches to identify translational research in genomics beyond bench to bedside from the biomedical literature. We apply the convolutional neural networks (CNNs) and support vector machines (SVMs) to the bench/bedside article classification on the weekly manual annotation data of the Public Health Genomics Knowledge Base database. Both classifiers employ salient features to determine the probability of curation-eligible publications, which can effectively reduce the workload of manual triage and curation process. We applied the CNNs and SVMs to an independent test set (n = 400), and the models achieved the F-measure of 0.80 and 0.74, respectively. We further tested the CNNs, which perform better results, on the routine annotation pipeline for 2 weeks and significantly reduced the effort and retrieved more appropriate research articles. Our approaches provide direct insight into the automated curation of genomic translational research beyond bench to bedside. The machine learning classifiers are found to be helpful for annotators to enhance the efficiency of manual curation.

Original languageEnglish
Article numberbaz010
JournalDatabase
Volume2019
Issue number1
DOIs
Publication statusPublished - 2019

All Science Journal Classification (ASJC) codes

  • General Agricultural and Biological Sciences
  • Information Systems
  • General Biochemistry,Genetics and Molecular Biology

Fingerprint

Dive into the research topics of 'Using deep learning to identify translational research in genomic medicine beyond bench to bedside'. Together they form a unique fingerprint.

Cite this