Using developed transdermal delivery chip to transfer drug for skin permeation

Zi Yu Liu; Lin Tsung Chiou; Chia Hsien Yeh; Yu-Cheng Lin

doi:10.1109/NANOMED.2009.5559067

Using developed transdermal delivery chip to transfer drug for skin permeation

Zi Yu Liu, Lin Tsung Chiou, Chia Hsien Yeh, Yu-Cheng Lin

Department of Engineering Science

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

This study developed a novel transdermal delivery chip system for delivering silver sulfadiazine into rat skin. The chip system was used Micro-Electro-Mechanical-Systems (MEMS) technology to fabricate and electroporation as experimental mechanism. The electrode would generate cell-penetrating electric field in the skin between electrodes when the voltage was applied. Microscope raman spectrometer was used to analyze spectral strength of drug which indicates the drug delivery effect. An excellent transdermal delivery could be obtained and the silver sulfadiazine could be delivered to 200 μ m deep in the rat skin when the voltage at 30 V and the frequency at 0.01 Hz were used. Therefore, this chip system could enhance effectively the transdermal delivery and delivery depth.

Original language	English
Title of host publication	2009 IEEE 3rd International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2009
Pages	294-297
Number of pages	4
DOIs	https://doi.org/10.1109/NANOMED.2009.5559067
Publication status	Published - 2009 Dec 1
Event	2009 IEEE 3rd International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2009 - Tainan, Taiwan Duration: 2009 Oct 18 → 2009 Oct 21

Publication series

Name	2009 IEEE 3rd International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2009

Other

Other	2009 IEEE 3rd International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2009
Country/Territory	Taiwan
City	Tainan
Period	09-10-18 → 09-10-21

All Science Journal Classification (ASJC) codes

Molecular Medicine
Pharmacology

Access to Document

10.1109/NANOMED.2009.5559067

Cite this

Liu, Z. Y., Chiou, L. T., Yeh, C. H., & Lin, Y.-C. (2009). Using developed transdermal delivery chip to transfer drug for skin permeation. In 2009 IEEE 3rd International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2009 (pp. 294-297). Article 5559067 (2009 IEEE 3rd International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2009). https://doi.org/10.1109/NANOMED.2009.5559067

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title = "Using developed transdermal delivery chip to transfer drug for skin permeation",

abstract = "This study developed a novel transdermal delivery chip system for delivering silver sulfadiazine into rat skin. The chip system was used Micro-Electro-Mechanical-Systems (MEMS) technology to fabricate and electroporation as experimental mechanism. The electrode would generate cell-penetrating electric field in the skin between electrodes when the voltage was applied. Microscope raman spectrometer was used to analyze spectral strength of drug which indicates the drug delivery effect. An excellent transdermal delivery could be obtained and the silver sulfadiazine could be delivered to 200 μ m deep in the rat skin when the voltage at 30 V and the frequency at 0.01 Hz were used. Therefore, this chip system could enhance effectively the transdermal delivery and delivery depth.",

author = "Liu, {Zi Yu} and Chiou, {Lin Tsung} and Yeh, {Chia Hsien} and Yu-Cheng Lin",

year = "2009",

month = dec,

day = "1",

doi = "10.1109/NANOMED.2009.5559067",

language = "English",

isbn = "9781424455287",

series = "2009 IEEE 3rd International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2009",

pages = "294--297",

booktitle = "2009 IEEE 3rd International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2009",

note = "2009 IEEE 3rd International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2009 ; Conference date: 18-10-2009 Through 21-10-2009",

}

Liu, ZY, Chiou, LT, Yeh, CH & Lin, Y-C 2009, Using developed transdermal delivery chip to transfer drug for skin permeation. in 2009 IEEE 3rd International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2009., 5559067, 2009 IEEE 3rd International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2009, pp. 294-297, 2009 IEEE 3rd International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2009, Tainan, Taiwan, 09-10-18. https://doi.org/10.1109/NANOMED.2009.5559067

Using developed transdermal delivery chip to transfer drug for skin permeation. / Liu, Zi Yu; Chiou, Lin Tsung; Yeh, Chia Hsien et al.
2009 IEEE 3rd International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2009. 2009. p. 294-297 5559067 (2009 IEEE 3rd International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2009).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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AU - Liu, Zi Yu

AU - Chiou, Lin Tsung

AU - Yeh, Chia Hsien

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N2 - This study developed a novel transdermal delivery chip system for delivering silver sulfadiazine into rat skin. The chip system was used Micro-Electro-Mechanical-Systems (MEMS) technology to fabricate and electroporation as experimental mechanism. The electrode would generate cell-penetrating electric field in the skin between electrodes when the voltage was applied. Microscope raman spectrometer was used to analyze spectral strength of drug which indicates the drug delivery effect. An excellent transdermal delivery could be obtained and the silver sulfadiazine could be delivered to 200 μ m deep in the rat skin when the voltage at 30 V and the frequency at 0.01 Hz were used. Therefore, this chip system could enhance effectively the transdermal delivery and delivery depth.

AB - This study developed a novel transdermal delivery chip system for delivering silver sulfadiazine into rat skin. The chip system was used Micro-Electro-Mechanical-Systems (MEMS) technology to fabricate and electroporation as experimental mechanism. The electrode would generate cell-penetrating electric field in the skin between electrodes when the voltage was applied. Microscope raman spectrometer was used to analyze spectral strength of drug which indicates the drug delivery effect. An excellent transdermal delivery could be obtained and the silver sulfadiazine could be delivered to 200 μ m deep in the rat skin when the voltage at 30 V and the frequency at 0.01 Hz were used. Therefore, this chip system could enhance effectively the transdermal delivery and delivery depth.

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Liu ZY, Chiou LT, Yeh CH, Lin YC. Using developed transdermal delivery chip to transfer drug for skin permeation. In 2009 IEEE 3rd International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2009. 2009. p. 294-297. 5559067. (2009 IEEE 3rd International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2009). doi: 10.1109/NANOMED.2009.5559067

Using developed transdermal delivery chip to transfer drug for skin permeation

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