TY - GEN
T1 - Using developed transdermal delivery chip to transfer drug for skin permeation
AU - Liu, Zi Yu
AU - Chiou, Lin Tsung
AU - Yeh, Chia Hsien
AU - Lin, Yu-Cheng
PY - 2009/12/1
Y1 - 2009/12/1
N2 - This study developed a novel transdermal delivery chip system for delivering silver sulfadiazine into rat skin. The chip system was used Micro-Electro-Mechanical-Systems (MEMS) technology to fabricate and electroporation as experimental mechanism. The electrode would generate cell-penetrating electric field in the skin between electrodes when the voltage was applied. Microscope raman spectrometer was used to analyze spectral strength of drug which indicates the drug delivery effect. An excellent transdermal delivery could be obtained and the silver sulfadiazine could be delivered to 200 μ m deep in the rat skin when the voltage at 30 V and the frequency at 0.01 Hz were used. Therefore, this chip system could enhance effectively the transdermal delivery and delivery depth.
AB - This study developed a novel transdermal delivery chip system for delivering silver sulfadiazine into rat skin. The chip system was used Micro-Electro-Mechanical-Systems (MEMS) technology to fabricate and electroporation as experimental mechanism. The electrode would generate cell-penetrating electric field in the skin between electrodes when the voltage was applied. Microscope raman spectrometer was used to analyze spectral strength of drug which indicates the drug delivery effect. An excellent transdermal delivery could be obtained and the silver sulfadiazine could be delivered to 200 μ m deep in the rat skin when the voltage at 30 V and the frequency at 0.01 Hz were used. Therefore, this chip system could enhance effectively the transdermal delivery and delivery depth.
UR - http://www.scopus.com/inward/record.url?scp=77958010257&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77958010257&partnerID=8YFLogxK
U2 - 10.1109/NANOMED.2009.5559067
DO - 10.1109/NANOMED.2009.5559067
M3 - Conference contribution
AN - SCOPUS:77958010257
SN - 9781424455287
T3 - 2009 IEEE 3rd International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2009
SP - 294
EP - 297
BT - 2009 IEEE 3rd International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2009
T2 - 2009 IEEE 3rd International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2009
Y2 - 18 October 2009 through 21 October 2009
ER -