Using developed transdermal delivery chip to transfer drug for skin permeation

Zi Yu Liu, Lin Tsung Chiou, Chia Hsien Yeh, Yu-Cheng Lin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This study developed a novel transdermal delivery chip system for delivering silver sulfadiazine into rat skin. The chip system was used Micro-Electro-Mechanical-Systems (MEMS) technology to fabricate and electroporation as experimental mechanism. The electrode would generate cell-penetrating electric field in the skin between electrodes when the voltage was applied. Microscope raman spectrometer was used to analyze spectral strength of drug which indicates the drug delivery effect. An excellent transdermal delivery could be obtained and the silver sulfadiazine could be delivered to 200 μ m deep in the rat skin when the voltage at 30 V and the frequency at 0.01 Hz were used. Therefore, this chip system could enhance effectively the transdermal delivery and delivery depth.

Original languageEnglish
Title of host publication2009 IEEE 3rd International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2009
Pages294-297
Number of pages4
DOIs
Publication statusPublished - 2009 Dec 1
Event2009 IEEE 3rd International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2009 - Tainan, Taiwan
Duration: 2009 Oct 182009 Oct 21

Publication series

Name2009 IEEE 3rd International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2009

Other

Other2009 IEEE 3rd International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2009
CountryTaiwan
CityTainan
Period09-10-1809-10-21

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

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