TY - GEN
T1 - Using Flexible Hybrid Electronics on a Miniaturized Non-invasive Bio-optical Sensor For Hemoglobin Detection
AU - Lee, Yu Chil
AU - Yu, Kai Lun
AU - Tsai, Shu An
AU - Shih, Pai Sheng
AU - Huang, Guo Sin
AU - Liu, Tien Chia
AU - Fu, Tzyy Wei
AU - Tseng, Sheng Hao
AU - Lin, Hung I.
AU - Chen, Jen Chun
AU - Fang, Jen Kuang
AU - Chang, Harrison
N1 - Publisher Copyright:
© 2024 IEEE.
PY - 2024
Y1 - 2024
N2 - Flexible hybrid electronics (FHE) is an emerging technology by integrating electronic devices and circuits onto flexible or stretchable substrates and packages. Skin chromophore concentration provides rich biomarker information for non-invasive healthcare applications. From algorithm developed on DRS (Diffusion Reflectance Spectroscopy), these biomarker data can be extracted by optics measurement of skin tissue absorption, and the reduced scattering coefficient. In this study, we choose blood hemoglobin as the detection target, and developed a wearable device with miniaturization evolved from a lab benchtop equipment to a small sized LED +PD structure. To fulfill this purpose, we first surveyed LEDs at 6 different wavelengths that meet most distinguished skin tissue absorption properties to hemoglobin. To mimic configuration of fiber probe and SDS (Source Detection Separation), where original DRS algorithm derived, we apply optical simulation to design grid topology with 12 LEDs and 6 PDs. Simulation result showed this topology design can derive absorption property of tissue phantom with good correlation to measurement result. In order to realize body conformal flexible bio optical sensor, as well as addressing the necessary light barrier miniaturization and component placement pitch in small SDS design, we developed LED and PD dice DB&WB process on FPC, and choose flexible optical and opaque LSR (Liquid Silicon Rubber) material that provide good workability in small area for the dispensing process. These process and material are critical to the development of miniaturized FHE. For functionality validation, firstly we validated critical parametric on optics to confirm the performance of design, material characteristics and stability of fabrication. Secondly, we verified device on known characterized tissue phantom for absorption and scattering coefficient extraction. The last, in-vivo hemoglobin measurement performed, and showed good data correlation with commodity device.
AB - Flexible hybrid electronics (FHE) is an emerging technology by integrating electronic devices and circuits onto flexible or stretchable substrates and packages. Skin chromophore concentration provides rich biomarker information for non-invasive healthcare applications. From algorithm developed on DRS (Diffusion Reflectance Spectroscopy), these biomarker data can be extracted by optics measurement of skin tissue absorption, and the reduced scattering coefficient. In this study, we choose blood hemoglobin as the detection target, and developed a wearable device with miniaturization evolved from a lab benchtop equipment to a small sized LED +PD structure. To fulfill this purpose, we first surveyed LEDs at 6 different wavelengths that meet most distinguished skin tissue absorption properties to hemoglobin. To mimic configuration of fiber probe and SDS (Source Detection Separation), where original DRS algorithm derived, we apply optical simulation to design grid topology with 12 LEDs and 6 PDs. Simulation result showed this topology design can derive absorption property of tissue phantom with good correlation to measurement result. In order to realize body conformal flexible bio optical sensor, as well as addressing the necessary light barrier miniaturization and component placement pitch in small SDS design, we developed LED and PD dice DB&WB process on FPC, and choose flexible optical and opaque LSR (Liquid Silicon Rubber) material that provide good workability in small area for the dispensing process. These process and material are critical to the development of miniaturized FHE. For functionality validation, firstly we validated critical parametric on optics to confirm the performance of design, material characteristics and stability of fabrication. Secondly, we verified device on known characterized tissue phantom for absorption and scattering coefficient extraction. The last, in-vivo hemoglobin measurement performed, and showed good data correlation with commodity device.
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U2 - 10.1109/ECTC51529.2024.00041
DO - 10.1109/ECTC51529.2024.00041
M3 - Conference contribution
AN - SCOPUS:85197678293
T3 - Proceedings - Electronic Components and Technology Conference
SP - 201
EP - 207
BT - Proceedings - IEEE 74th Electronic Components and Technology Conference, ECTC 2024
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 74th IEEE Electronic Components and Technology Conference, ECTC 2024
Y2 - 28 May 2024 through 31 May 2024
ER -