Using modified contour deformable model to quantitatively estimate ultrasound parameters for osteoporosis assessment

Yung Fu Chen, Yi Chun Du, Yi Ting Tsai, Tainsong Chen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Osteoporosis is a systemic skeletal disease, which is characterized by low bone mass and micro-architectural deterioration of bone tissue, leading to bone fragility. Finding an effective method for prevention and early diagnosis of the disease is very important. Several parameters, including broadband ultra-sound attenuation (BUA), speed of sound (SOS), and stiffness index (STI), have been used to measure the characteristics of bone tissues. In this paper, we proposed a method, namely modified contour deformable model (MCDM), bases on the active contour model (ACM) and active shape model (ASM) for automatically detecting the calcaneus contour from quantitative ultrasound (QUS) parametric images. The results show that the difference between the contours detected by the MCDM and the true boundary for the phantom is less than one pixel. By comparing the phantom ROIs, significant relationship was found between contour mean and bone mineral density (BMD) with R=0.99. The influence of selecting different ROI diameters (12, 14, 16 and 18 mm) and different region-selecting methods, including fixed region (ROIcir), automatic circular region (ROI cir) and calcaneal contour region (ROIanat), were evaluated for testing human subjects. Measurements with large ROI diameters, especially using fixed region, result in high position errors (10-45%). The precision errors of the measured ultrasonic parameters for ROIanat are smaller than ROIfix and ROIcir. In conclusion, ROIanat, provides more accurate measurement of ultrasonic parameters for the evaluation of osteoporosis and is useful for clinical application.

Original languageEnglish
Title of host publicationMedical Biometrics - First International Conference, ICMB 2008, Proceedings
Pages208-215
Number of pages8
Publication statusPublished - 2008 Feb 6
Event1st International Conference on Medical Biometrics, ICMB 2008 - Hong Kong, Hong Kong
Duration: 2008 Jan 42008 Jan 5

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume4901 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other1st International Conference on Medical Biometrics, ICMB 2008
CountryHong Kong
CityHong Kong
Period08-01-0408-01-05

All Science Journal Classification (ASJC) codes

  • Theoretical Computer Science
  • Computer Science(all)

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    Chen, Y. F., Du, Y. C., Tsai, Y. T., & Chen, T. (2008). Using modified contour deformable model to quantitatively estimate ultrasound parameters for osteoporosis assessment. In Medical Biometrics - First International Conference, ICMB 2008, Proceedings (pp. 208-215). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 4901 LNCS).