Using pulsed dye laser to treat sebaceous hyperplasia: comparison of short and long pulse-duration pulsed dye laser

Sheng-Pei Wang, Ying Jui Chang, Ching Chi Chi, Shu Hui Wang, Tsung Hua Tsai

Research output: Contribution to journalArticle

Abstract

Background Pulsed dye laser (PDL) is effective in treating sebaceous hyperplasia (SH). However, only short pulse-duration PDL (SPDL) has been used in previous studies. Objectives To determine whether long pulse-duration PDL (LPDL) can achieve comparable efficacy in treating SH with fewer side effects versus SPDL. Methods Eight patients with a total of 75 SH lesions were enrolled. Each SH lesion was randomized to be treated with two sessions of 595-nm SPDL with 0.45-millisecond pulse duration or 595-nm LPDL with 20-millisecond pulse duration. The second session was performed 4 weeks after the first session. Side effects including pain and post-treatment purpura were recorded. Follow-up examinations were conducted at 1 week and 4 weeks after the first session, and at 1 week, 4 weeks, and 8 weeks after the second session for repeated photography and assessing the diameter and thickness of each lesion, post-treatment purpura, and other adverse events. Results All SH lesions responded to two sessions of PDL treatments. The reduction ratio of lesion diameter was 76.3% in the SPDL group and 70.0% in the LPDL group after two sessions of treatments (p = 0.644). The reduction ratio of lesion thickness was 79.6% in the SPDL group and 72.7% in the LPDL group after two sessions of treatment (p = 0.187). The mean intensity of pain was 3.13 on a 0–10-point scale for SPDL and 3.60 for LPDL (p = 0.660). The intensity of immediate post-treatment purpura was 4.13 on a 0–5-point scale for SPDL, and 1.80 for LPDL (p < 0.001). Some of the lesions treated by SPDL underwent an erosive stage. No scarring or discoloration was noted at 8 weeks after treatment. Conclusions While SPDL and LPDL have comparable efficacy in treating SH after two sessions of treatment, LPDL can provide a shorter and aesthetically better recovery time.

Original languageEnglish
Pages (from-to)119-123
Number of pages5
JournalDermatologica Sinica
Volume35
Issue number3
DOIs
Publication statusPublished - 2017 Sep 1

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Dye Lasers
Hyperplasia
Purpura
Therapeutics
Pain
Photography
Cicatrix

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Wang, Sheng-Pei ; Chang, Ying Jui ; Chi, Ching Chi ; Wang, Shu Hui ; Tsai, Tsung Hua. / Using pulsed dye laser to treat sebaceous hyperplasia : comparison of short and long pulse-duration pulsed dye laser. In: Dermatologica Sinica. 2017 ; Vol. 35, No. 3. pp. 119-123.
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title = "Using pulsed dye laser to treat sebaceous hyperplasia: comparison of short and long pulse-duration pulsed dye laser",
abstract = "Background Pulsed dye laser (PDL) is effective in treating sebaceous hyperplasia (SH). However, only short pulse-duration PDL (SPDL) has been used in previous studies. Objectives To determine whether long pulse-duration PDL (LPDL) can achieve comparable efficacy in treating SH with fewer side effects versus SPDL. Methods Eight patients with a total of 75 SH lesions were enrolled. Each SH lesion was randomized to be treated with two sessions of 595-nm SPDL with 0.45-millisecond pulse duration or 595-nm LPDL with 20-millisecond pulse duration. The second session was performed 4 weeks after the first session. Side effects including pain and post-treatment purpura were recorded. Follow-up examinations were conducted at 1 week and 4 weeks after the first session, and at 1 week, 4 weeks, and 8 weeks after the second session for repeated photography and assessing the diameter and thickness of each lesion, post-treatment purpura, and other adverse events. Results All SH lesions responded to two sessions of PDL treatments. The reduction ratio of lesion diameter was 76.3{\%} in the SPDL group and 70.0{\%} in the LPDL group after two sessions of treatments (p = 0.644). The reduction ratio of lesion thickness was 79.6{\%} in the SPDL group and 72.7{\%} in the LPDL group after two sessions of treatment (p = 0.187). The mean intensity of pain was 3.13 on a 0–10-point scale for SPDL and 3.60 for LPDL (p = 0.660). The intensity of immediate post-treatment purpura was 4.13 on a 0–5-point scale for SPDL, and 1.80 for LPDL (p < 0.001). Some of the lesions treated by SPDL underwent an erosive stage. No scarring or discoloration was noted at 8 weeks after treatment. Conclusions While SPDL and LPDL have comparable efficacy in treating SH after two sessions of treatment, LPDL can provide a shorter and aesthetically better recovery time.",
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Using pulsed dye laser to treat sebaceous hyperplasia : comparison of short and long pulse-duration pulsed dye laser. / Wang, Sheng-Pei; Chang, Ying Jui; Chi, Ching Chi; Wang, Shu Hui; Tsai, Tsung Hua.

In: Dermatologica Sinica, Vol. 35, No. 3, 01.09.2017, p. 119-123.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Using pulsed dye laser to treat sebaceous hyperplasia

T2 - comparison of short and long pulse-duration pulsed dye laser

AU - Wang, Sheng-Pei

AU - Chang, Ying Jui

AU - Chi, Ching Chi

AU - Wang, Shu Hui

AU - Tsai, Tsung Hua

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N2 - Background Pulsed dye laser (PDL) is effective in treating sebaceous hyperplasia (SH). However, only short pulse-duration PDL (SPDL) has been used in previous studies. Objectives To determine whether long pulse-duration PDL (LPDL) can achieve comparable efficacy in treating SH with fewer side effects versus SPDL. Methods Eight patients with a total of 75 SH lesions were enrolled. Each SH lesion was randomized to be treated with two sessions of 595-nm SPDL with 0.45-millisecond pulse duration or 595-nm LPDL with 20-millisecond pulse duration. The second session was performed 4 weeks after the first session. Side effects including pain and post-treatment purpura were recorded. Follow-up examinations were conducted at 1 week and 4 weeks after the first session, and at 1 week, 4 weeks, and 8 weeks after the second session for repeated photography and assessing the diameter and thickness of each lesion, post-treatment purpura, and other adverse events. Results All SH lesions responded to two sessions of PDL treatments. The reduction ratio of lesion diameter was 76.3% in the SPDL group and 70.0% in the LPDL group after two sessions of treatments (p = 0.644). The reduction ratio of lesion thickness was 79.6% in the SPDL group and 72.7% in the LPDL group after two sessions of treatment (p = 0.187). The mean intensity of pain was 3.13 on a 0–10-point scale for SPDL and 3.60 for LPDL (p = 0.660). The intensity of immediate post-treatment purpura was 4.13 on a 0–5-point scale for SPDL, and 1.80 for LPDL (p < 0.001). Some of the lesions treated by SPDL underwent an erosive stage. No scarring or discoloration was noted at 8 weeks after treatment. Conclusions While SPDL and LPDL have comparable efficacy in treating SH after two sessions of treatment, LPDL can provide a shorter and aesthetically better recovery time.

AB - Background Pulsed dye laser (PDL) is effective in treating sebaceous hyperplasia (SH). However, only short pulse-duration PDL (SPDL) has been used in previous studies. Objectives To determine whether long pulse-duration PDL (LPDL) can achieve comparable efficacy in treating SH with fewer side effects versus SPDL. Methods Eight patients with a total of 75 SH lesions were enrolled. Each SH lesion was randomized to be treated with two sessions of 595-nm SPDL with 0.45-millisecond pulse duration or 595-nm LPDL with 20-millisecond pulse duration. The second session was performed 4 weeks after the first session. Side effects including pain and post-treatment purpura were recorded. Follow-up examinations were conducted at 1 week and 4 weeks after the first session, and at 1 week, 4 weeks, and 8 weeks after the second session for repeated photography and assessing the diameter and thickness of each lesion, post-treatment purpura, and other adverse events. Results All SH lesions responded to two sessions of PDL treatments. The reduction ratio of lesion diameter was 76.3% in the SPDL group and 70.0% in the LPDL group after two sessions of treatments (p = 0.644). The reduction ratio of lesion thickness was 79.6% in the SPDL group and 72.7% in the LPDL group after two sessions of treatment (p = 0.187). The mean intensity of pain was 3.13 on a 0–10-point scale for SPDL and 3.60 for LPDL (p = 0.660). The intensity of immediate post-treatment purpura was 4.13 on a 0–5-point scale for SPDL, and 1.80 for LPDL (p < 0.001). Some of the lesions treated by SPDL underwent an erosive stage. No scarring or discoloration was noted at 8 weeks after treatment. Conclusions While SPDL and LPDL have comparable efficacy in treating SH after two sessions of treatment, LPDL can provide a shorter and aesthetically better recovery time.

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