Using the micro-array electrode chip and AC signals to generate the electric field effect on cell migration

Chia Hsien Yeh, Po Yu To, Tai Hsin Hsu, Yu Cheng Lin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We have successfully fabricated the micro-array electrode chip with different gap sizes by Micro-Electro-Mechanical-Systems (MEMS) technology and generated the moving electric field to drive cells to migrate by employing AC signal. Our strategy is to simulate the ramp waveform signal with various gap sizes (10 μm, 20 μm, and 30 μm) to examine the optimal moving electric field by the ANSYS 9.0 software. The electrode with 10 μm gap can generate the better moving electric field effect on cell migration than that of other gap sizes. In the experiments, when fixing the electric field strength at 0.6 V/mm in 100 kHz, the migration velocity of the cells was 21.25 μm/h in the micro-array electrode chip with the gap of 10 μm, and the direction of cell migration could be controlled by the moving electric field. Moreover, the cell migration was more obvious when the driving frequency is over 50 kHz. This method for cell migration could be applied to cell manipulation of bio-applications.

Original languageEnglish
Pages (from-to)28-33
Number of pages6
JournalSensors and Actuators, B: Chemical
Volume170
DOIs
Publication statusPublished - 2012 Jul 31

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

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