Uterine choriocarcinoma accompanied by an extremely high human chorionic gonadotropin level and thyrotoxicosis

Tsung Ying Hsieh, Keng-Fu Hsu, Pao-Lin Kuo, Soon Cen Huang

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The conventional treatments given to a 24-year-old woman with metastatic uterine choriocarcinoma and clinical and biochemical thyrotoxicosis did not appear to have any effect, probably due to an extremely high serum human chorionic gonadotropin (hCG) level which was up to 11 910 000 mIU/mL, and were initially underscored in light of the 'high-dose hook effect'. To our knowledge, no extremely high hCG level in a uterine choriocarcinoma patient has been reported in the literature. Her decapacitating symptoms subsided after the first course of chemotherapy by etoposide, methotrexate, and actinomycin D-cyclophosphamide and vincristine (EMA-CO) regimen. The serum hCG level, which reflects the quantification of host tumor burden, returned to the reference range after the fifth course of chemotherapy and the thyroid function reached euthyroid status before the third course of chemotherapy; two final courses were administered after the hCG level became undetectable. Two years after remission of disease, the patient experienced a normal pregnancy, and a term baby girl was delivered vaginally. No recurrence of uterine choriocarcinoma has been noted for 7 years.

Original languageEnglish
Pages (from-to)274-278
Number of pages5
JournalJournal of Obstetrics and Gynaecology Research
Volume34
Issue number2
DOIs
Publication statusPublished - 2008 Apr 1

Fingerprint

Choriocarcinoma
Thyrotoxicosis
Chorionic Gonadotropin
Drug Therapy
Dactinomycin
Vincristine
Etoposide
Tumor Burden
Serum
Methotrexate
Cyclophosphamide
Thyroid Gland
Reference Values
Recurrence
Pregnancy
Therapeutics

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

Cite this

@article{e7842295f4a0475ab01d6712d4469a23,
title = "Uterine choriocarcinoma accompanied by an extremely high human chorionic gonadotropin level and thyrotoxicosis",
abstract = "The conventional treatments given to a 24-year-old woman with metastatic uterine choriocarcinoma and clinical and biochemical thyrotoxicosis did not appear to have any effect, probably due to an extremely high serum human chorionic gonadotropin (hCG) level which was up to 11 910 000 mIU/mL, and were initially underscored in light of the 'high-dose hook effect'. To our knowledge, no extremely high hCG level in a uterine choriocarcinoma patient has been reported in the literature. Her decapacitating symptoms subsided after the first course of chemotherapy by etoposide, methotrexate, and actinomycin D-cyclophosphamide and vincristine (EMA-CO) regimen. The serum hCG level, which reflects the quantification of host tumor burden, returned to the reference range after the fifth course of chemotherapy and the thyroid function reached euthyroid status before the third course of chemotherapy; two final courses were administered after the hCG level became undetectable. Two years after remission of disease, the patient experienced a normal pregnancy, and a term baby girl was delivered vaginally. No recurrence of uterine choriocarcinoma has been noted for 7 years.",
author = "Hsieh, {Tsung Ying} and Keng-Fu Hsu and Pao-Lin Kuo and Huang, {Soon Cen}",
year = "2008",
month = "4",
day = "1",
doi = "10.1111/j.1447-0756.2008.00770.x",
language = "English",
volume = "34",
pages = "274--278",
journal = "Journal of Obstetrics and Gynaecology Research",
issn = "1341-8076",
publisher = "Blackwell Publishing Asia",
number = "2",

}

Uterine choriocarcinoma accompanied by an extremely high human chorionic gonadotropin level and thyrotoxicosis. / Hsieh, Tsung Ying; Hsu, Keng-Fu; Kuo, Pao-Lin; Huang, Soon Cen.

In: Journal of Obstetrics and Gynaecology Research, Vol. 34, No. 2, 01.04.2008, p. 274-278.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Uterine choriocarcinoma accompanied by an extremely high human chorionic gonadotropin level and thyrotoxicosis

AU - Hsieh, Tsung Ying

AU - Hsu, Keng-Fu

AU - Kuo, Pao-Lin

AU - Huang, Soon Cen

PY - 2008/4/1

Y1 - 2008/4/1

N2 - The conventional treatments given to a 24-year-old woman with metastatic uterine choriocarcinoma and clinical and biochemical thyrotoxicosis did not appear to have any effect, probably due to an extremely high serum human chorionic gonadotropin (hCG) level which was up to 11 910 000 mIU/mL, and were initially underscored in light of the 'high-dose hook effect'. To our knowledge, no extremely high hCG level in a uterine choriocarcinoma patient has been reported in the literature. Her decapacitating symptoms subsided after the first course of chemotherapy by etoposide, methotrexate, and actinomycin D-cyclophosphamide and vincristine (EMA-CO) regimen. The serum hCG level, which reflects the quantification of host tumor burden, returned to the reference range after the fifth course of chemotherapy and the thyroid function reached euthyroid status before the third course of chemotherapy; two final courses were administered after the hCG level became undetectable. Two years after remission of disease, the patient experienced a normal pregnancy, and a term baby girl was delivered vaginally. No recurrence of uterine choriocarcinoma has been noted for 7 years.

AB - The conventional treatments given to a 24-year-old woman with metastatic uterine choriocarcinoma and clinical and biochemical thyrotoxicosis did not appear to have any effect, probably due to an extremely high serum human chorionic gonadotropin (hCG) level which was up to 11 910 000 mIU/mL, and were initially underscored in light of the 'high-dose hook effect'. To our knowledge, no extremely high hCG level in a uterine choriocarcinoma patient has been reported in the literature. Her decapacitating symptoms subsided after the first course of chemotherapy by etoposide, methotrexate, and actinomycin D-cyclophosphamide and vincristine (EMA-CO) regimen. The serum hCG level, which reflects the quantification of host tumor burden, returned to the reference range after the fifth course of chemotherapy and the thyroid function reached euthyroid status before the third course of chemotherapy; two final courses were administered after the hCG level became undetectable. Two years after remission of disease, the patient experienced a normal pregnancy, and a term baby girl was delivered vaginally. No recurrence of uterine choriocarcinoma has been noted for 7 years.

UR - http://www.scopus.com/inward/record.url?scp=42149097232&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=42149097232&partnerID=8YFLogxK

U2 - 10.1111/j.1447-0756.2008.00770.x

DO - 10.1111/j.1447-0756.2008.00770.x

M3 - Article

VL - 34

SP - 274

EP - 278

JO - Journal of Obstetrics and Gynaecology Research

JF - Journal of Obstetrics and Gynaecology Research

SN - 1341-8076

IS - 2

ER -