UV-guided isolation of polyynes and polyenes from the roots of Codonopsis pilosula

Chih Hua Chao, Shin Hun Juang, Hsiu Hui Chan, De Yang Shen, Yu Ren Liao, Hung Cheng Shih, Chieh Hung Huang, Ju Chien Cheng, Fu An Chen, Hsin-Yi Hung, Tian-Shung Wu

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

The UV-guided isolation of polyacetylenes from the crude extract of Codonopsis pilosula has successfully led to the characterization of five new polyynes, pilosulynes A-E (1-5), and two new polyenes, pilosulynes F and G (6 and 7), as well as five known analogues (8-12). Their structures were determined by spectroscopic methods, including ICD and 1D/2D NMR experiments. The absolute configurations of the 6,7-diol moiety of the isolated compounds were determined by the Snatzke's method, which revealed an induced circular dichroism after the addition of dimolybdenum tetraacetate in DMSO. Compound 6 exhibited anti-HCV activity in the HCVcc infection assay with an EC50 value of 47.2 μM.

Original languageEnglish
Pages (from-to)41324-41331
Number of pages8
JournalRSC Advances
Volume5
Issue number52
DOIs
Publication statusPublished - 2015 Jan 1

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

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