Abstract
Injection of staphylococcal enterotoxin B (SEE) into BALB/c mice induced the depletion of V(β)8+ T-cells which were either V(β)8+ CD4+ or V(β)8+ CD8+ cells. The CD8 molecule on V(β)+ CD8+ cells was found to decrease at 72 h after SEE treatment while the V(β)8 molecule on V(β)8+ cells or CD4 molecule on V(β)8+ CD4+ cells was not affected. Furthermore, a subpopulation of V(β)8+ CD4- CD8- T-cells was also induced after SEE-priming. This subpopulation can be found in spleen or lymph nodes. It was small in size and constituted the major part of V(β)8+ cells in lymph nodes at 72 h after SEB-priming. Some of the V(β)8+ CD4- CD8- T-cells might be autoreactive because they could be stimulated to proliferative by syngenic mitomycin C-treated splenocytes.
| Original language | English |
|---|---|
| Pages (from-to) | 85-91 |
| Number of pages | 7 |
| Journal | Immunology Letters |
| Volume | 55 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1997 Feb 1 |
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All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology
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V(β)8+ CD4- CD8- subpopulation induced by staphylococcal enterotoxin B. / Chou, Miao Chen; Lee, Shiour Ching; Lin, Yee-Shin; Lei, Huan Yao.
In: Immunology Letters, Vol. 55, No. 2, 01.02.1997, p. 85-91.Research output: Contribution to journal › Article
TY - JOUR
T1 - V(β)8+ CD4- CD8- subpopulation induced by staphylococcal enterotoxin B
AU - Chou, Miao Chen
AU - Lee, Shiour Ching
AU - Lin, Yee-Shin
AU - Lei, Huan Yao
PY - 1997/2/1
Y1 - 1997/2/1
N2 - Injection of staphylococcal enterotoxin B (SEE) into BALB/c mice induced the depletion of V(β)8+ T-cells which were either V(β)8+ CD4+ or V(β)8+ CD8+ cells. The CD8 molecule on V(β)+ CD8+ cells was found to decrease at 72 h after SEE treatment while the V(β)8 molecule on V(β)8+ cells or CD4 molecule on V(β)8+ CD4+ cells was not affected. Furthermore, a subpopulation of V(β)8+ CD4- CD8- T-cells was also induced after SEE-priming. This subpopulation can be found in spleen or lymph nodes. It was small in size and constituted the major part of V(β)8+ cells in lymph nodes at 72 h after SEB-priming. Some of the V(β)8+ CD4- CD8- T-cells might be autoreactive because they could be stimulated to proliferative by syngenic mitomycin C-treated splenocytes.
AB - Injection of staphylococcal enterotoxin B (SEE) into BALB/c mice induced the depletion of V(β)8+ T-cells which were either V(β)8+ CD4+ or V(β)8+ CD8+ cells. The CD8 molecule on V(β)+ CD8+ cells was found to decrease at 72 h after SEE treatment while the V(β)8 molecule on V(β)8+ cells or CD4 molecule on V(β)8+ CD4+ cells was not affected. Furthermore, a subpopulation of V(β)8+ CD4- CD8- T-cells was also induced after SEE-priming. This subpopulation can be found in spleen or lymph nodes. It was small in size and constituted the major part of V(β)8+ cells in lymph nodes at 72 h after SEB-priming. Some of the V(β)8+ CD4- CD8- T-cells might be autoreactive because they could be stimulated to proliferative by syngenic mitomycin C-treated splenocytes.
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U2 - 10.1016/S0165-2478(97)02689-8
DO - 10.1016/S0165-2478(97)02689-8
M3 - Article
VL - 55
SP - 85
EP - 91
JO - Immunology Letters
JF - Immunology Letters
SN - 0165-2478
IS - 2
ER -