Injection of staphylococcal enterotoxin B (SEE) into BALB/c mice induced the depletion of V(β)8+ T-cells which were either V(β)8+ CD4+ or V(β)8+ CD8+ cells. The CD8 molecule on V(β)+ CD8+ cells was found to decrease at 72 h after SEE treatment while the V(β)8 molecule on V(β)8+ cells or CD4 molecule on V(β)8+ CD4+ cells was not affected. Furthermore, a subpopulation of V(β)8+ CD4- CD8- T-cells was also induced after SEE-priming. This subpopulation can be found in spleen or lymph nodes. It was small in size and constituted the major part of V(β)8+ cells in lymph nodes at 72 h after SEB-priming. Some of the V(β)8+ CD4- CD8- T-cells might be autoreactive because they could be stimulated to proliferative by syngenic mitomycin C-treated splenocytes.
All Science Journal Classification (ASJC) codes
- Immunology and Allergy