Value of layer-specific strain distribution patterns in hypertrophied myocardium from different etiologies

Mu shiang Huang, Wen Huang Lee, Huey Ru Tsai, Yen Wen Liu, Ping Yen Liu, Wei Chuan Tsai

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Intrinsic myocardial mechanics might have different patterns because of the different etiologies of myocardial hypertrophy. We used layer-specific strain to compare those with aortic stenosis (AS) and hypertrophic cardiomyopathy (HCM) and examined the differences in strain distribution pattern and for their clinical implications. Methods: Comprehensive echocardiography was done in 3 groups: 129 with moderate-to-severe AS, 172 consecutive patients with HCM, and 58 healthy controls. Left ventricle (LV) layer-specific deformation parameters were obtained using two-dimensional speckle tracking echocardiography. The transmural strain gradient was defined as the strain difference between subendocardial and subepicardial myocardium. Both diseased groups were further divided based on the median value of transmural strain gradient for the hemodynamics correlation. Results: Compared with the HCM group, the AS group had more preserved transmural longitudinal strain gradient (4.49 ± 1.3% vs. 3.61 ± 1.2%, p < 0.001), which was not significantly different from that of the healthy controls (4.49 ± 1.3% vs. 4.54 ± 1.0%, p = 0.975). And only in AS group the transmural circumferential strain correlated with myocardium mass index (r = −0.237, p = 0.008), and the hemodynamic profiles (LV ejection fraction and LA pressure) were correlated well with transmural strain gradient, in that the lower subgroup had a significantly lower LV ejection fraction and higher average E/E′. Conclusions: Myocardium hypertrophy from different etiology resulted in different layer-specific strain distribution pattern. The loss of an adequate transmural strain gradient correlated with hemodynamics and might reflect intrinsic myocardial dysfunction.

Original languageEnglish
Pages (from-to)69-75
Number of pages7
JournalInternational Journal of Cardiology
Volume281
DOIs
Publication statusPublished - 2019 Apr 15

Fingerprint

Aortic Valve Stenosis
Hypertrophic Cardiomyopathy
Myocardium
Heart Ventricles
Hemodynamics
Hypertrophy
Echocardiography
Mechanics
Pressure

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

@article{dedae33f7fed44e2b10f4e9d8a6709a1,
title = "Value of layer-specific strain distribution patterns in hypertrophied myocardium from different etiologies",
abstract = "Background: Intrinsic myocardial mechanics might have different patterns because of the different etiologies of myocardial hypertrophy. We used layer-specific strain to compare those with aortic stenosis (AS) and hypertrophic cardiomyopathy (HCM) and examined the differences in strain distribution pattern and for their clinical implications. Methods: Comprehensive echocardiography was done in 3 groups: 129 with moderate-to-severe AS, 172 consecutive patients with HCM, and 58 healthy controls. Left ventricle (LV) layer-specific deformation parameters were obtained using two-dimensional speckle tracking echocardiography. The transmural strain gradient was defined as the strain difference between subendocardial and subepicardial myocardium. Both diseased groups were further divided based on the median value of transmural strain gradient for the hemodynamics correlation. Results: Compared with the HCM group, the AS group had more preserved transmural longitudinal strain gradient (4.49 ± 1.3{\%} vs. 3.61 ± 1.2{\%}, p < 0.001), which was not significantly different from that of the healthy controls (4.49 ± 1.3{\%} vs. 4.54 ± 1.0{\%}, p = 0.975). And only in AS group the transmural circumferential strain correlated with myocardium mass index (r = −0.237, p = 0.008), and the hemodynamic profiles (LV ejection fraction and LA pressure) were correlated well with transmural strain gradient, in that the lower subgroup had a significantly lower LV ejection fraction and higher average E/E′. Conclusions: Myocardium hypertrophy from different etiology resulted in different layer-specific strain distribution pattern. The loss of an adequate transmural strain gradient correlated with hemodynamics and might reflect intrinsic myocardial dysfunction.",
author = "Huang, {Mu shiang} and Lee, {Wen Huang} and Tsai, {Huey Ru} and Liu, {Yen Wen} and Liu, {Ping Yen} and Tsai, {Wei Chuan}",
year = "2019",
month = "4",
day = "15",
doi = "10.1016/j.ijcard.2019.01.044",
language = "English",
volume = "281",
pages = "69--75",
journal = "International Journal of Cardiology",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Value of layer-specific strain distribution patterns in hypertrophied myocardium from different etiologies

AU - Huang, Mu shiang

AU - Lee, Wen Huang

AU - Tsai, Huey Ru

AU - Liu, Yen Wen

AU - Liu, Ping Yen

AU - Tsai, Wei Chuan

PY - 2019/4/15

Y1 - 2019/4/15

N2 - Background: Intrinsic myocardial mechanics might have different patterns because of the different etiologies of myocardial hypertrophy. We used layer-specific strain to compare those with aortic stenosis (AS) and hypertrophic cardiomyopathy (HCM) and examined the differences in strain distribution pattern and for their clinical implications. Methods: Comprehensive echocardiography was done in 3 groups: 129 with moderate-to-severe AS, 172 consecutive patients with HCM, and 58 healthy controls. Left ventricle (LV) layer-specific deformation parameters were obtained using two-dimensional speckle tracking echocardiography. The transmural strain gradient was defined as the strain difference between subendocardial and subepicardial myocardium. Both diseased groups were further divided based on the median value of transmural strain gradient for the hemodynamics correlation. Results: Compared with the HCM group, the AS group had more preserved transmural longitudinal strain gradient (4.49 ± 1.3% vs. 3.61 ± 1.2%, p < 0.001), which was not significantly different from that of the healthy controls (4.49 ± 1.3% vs. 4.54 ± 1.0%, p = 0.975). And only in AS group the transmural circumferential strain correlated with myocardium mass index (r = −0.237, p = 0.008), and the hemodynamic profiles (LV ejection fraction and LA pressure) were correlated well with transmural strain gradient, in that the lower subgroup had a significantly lower LV ejection fraction and higher average E/E′. Conclusions: Myocardium hypertrophy from different etiology resulted in different layer-specific strain distribution pattern. The loss of an adequate transmural strain gradient correlated with hemodynamics and might reflect intrinsic myocardial dysfunction.

AB - Background: Intrinsic myocardial mechanics might have different patterns because of the different etiologies of myocardial hypertrophy. We used layer-specific strain to compare those with aortic stenosis (AS) and hypertrophic cardiomyopathy (HCM) and examined the differences in strain distribution pattern and for their clinical implications. Methods: Comprehensive echocardiography was done in 3 groups: 129 with moderate-to-severe AS, 172 consecutive patients with HCM, and 58 healthy controls. Left ventricle (LV) layer-specific deformation parameters were obtained using two-dimensional speckle tracking echocardiography. The transmural strain gradient was defined as the strain difference between subendocardial and subepicardial myocardium. Both diseased groups were further divided based on the median value of transmural strain gradient for the hemodynamics correlation. Results: Compared with the HCM group, the AS group had more preserved transmural longitudinal strain gradient (4.49 ± 1.3% vs. 3.61 ± 1.2%, p < 0.001), which was not significantly different from that of the healthy controls (4.49 ± 1.3% vs. 4.54 ± 1.0%, p = 0.975). And only in AS group the transmural circumferential strain correlated with myocardium mass index (r = −0.237, p = 0.008), and the hemodynamic profiles (LV ejection fraction and LA pressure) were correlated well with transmural strain gradient, in that the lower subgroup had a significantly lower LV ejection fraction and higher average E/E′. Conclusions: Myocardium hypertrophy from different etiology resulted in different layer-specific strain distribution pattern. The loss of an adequate transmural strain gradient correlated with hemodynamics and might reflect intrinsic myocardial dysfunction.

UR - http://www.scopus.com/inward/record.url?scp=85060755037&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060755037&partnerID=8YFLogxK

U2 - 10.1016/j.ijcard.2019.01.044

DO - 10.1016/j.ijcard.2019.01.044

M3 - Article

C2 - 30711265

AN - SCOPUS:85060755037

VL - 281

SP - 69

EP - 75

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

ER -