TY - JOUR
T1 - Vancomycin-modified LaB6@SiO2/Fe3O 4 composite nanoparticles for near-infrared photothermal ablation of bacteria
AU - Lai, Bo Hung
AU - Chen, Dong Hwang
N1 - Funding Information:
This work was financially supported by the National Science Council of the Republic of China (NSC 100-2221-E-006-164-MY2 ).
PY - 2013/7
Y1 - 2013/7
N2 - LaB6 nanoparticles possess excellent near-infrared (NIR) photothermal conversion properties. Vancomycin can interact strongly with a broad range of Gram-positive and Gram-negative bacteria. Fe3O 4 nanoparticles could be used as the carrier for magnetic separation. In this work, vancomycin and Fe3O4 nanoparticles were successfully bound onto the surface of LaB6 nanoparticles with a silica coating and carboxyl functionalization to fabricate vancomycin-modified LaB6@SiO2/Fe3O4 (Van-LaB 6@SiO2/Fe3O4) composite nanoparticles as a novel nanomaterial for the NIR photothermal ablation of bacteria. From the analyses of absorption spectra, transmission electron microscopy images and X-ray diffraction patterns, the formation of Van-LaB 6@SiO2/Fe3O4 composite nanoparticles was confirmed. The resulting Van-LaB6@SiO2/Fe 3O4 composite nanoparticles possessed nearly superparamagnetic properties, retained the excellent NIR photothermal conversion property of LaB6 nanoparticles and could capture the bacteria Staphylococcus aureus and Escherichia coli efficiently. Owing to these capabilities, they were demonstrated to be quite efficient for the magnetic separation and NIR photothermal ablation of S. aureus and E. coli. Furthermore, the magnetic property made the Van-LaB6@SiO2/Fe 3O4 composite nanoparticles useful for the magnetic assembling of bacteria, which could further enhance the photothermal ablation efficiency.
AB - LaB6 nanoparticles possess excellent near-infrared (NIR) photothermal conversion properties. Vancomycin can interact strongly with a broad range of Gram-positive and Gram-negative bacteria. Fe3O 4 nanoparticles could be used as the carrier for magnetic separation. In this work, vancomycin and Fe3O4 nanoparticles were successfully bound onto the surface of LaB6 nanoparticles with a silica coating and carboxyl functionalization to fabricate vancomycin-modified LaB6@SiO2/Fe3O4 (Van-LaB 6@SiO2/Fe3O4) composite nanoparticles as a novel nanomaterial for the NIR photothermal ablation of bacteria. From the analyses of absorption spectra, transmission electron microscopy images and X-ray diffraction patterns, the formation of Van-LaB 6@SiO2/Fe3O4 composite nanoparticles was confirmed. The resulting Van-LaB6@SiO2/Fe 3O4 composite nanoparticles possessed nearly superparamagnetic properties, retained the excellent NIR photothermal conversion property of LaB6 nanoparticles and could capture the bacteria Staphylococcus aureus and Escherichia coli efficiently. Owing to these capabilities, they were demonstrated to be quite efficient for the magnetic separation and NIR photothermal ablation of S. aureus and E. coli. Furthermore, the magnetic property made the Van-LaB6@SiO2/Fe 3O4 composite nanoparticles useful for the magnetic assembling of bacteria, which could further enhance the photothermal ablation efficiency.
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U2 - 10.1016/j.actbio.2013.03.023
DO - 10.1016/j.actbio.2013.03.023
M3 - Article
C2 - 23535232
AN - SCOPUS:84878311926
VL - 9
SP - 7573
EP - 7579
JO - Acta Biomaterialia
JF - Acta Biomaterialia
SN - 1742-7061
IS - 7
ER -