Variation of types of alcoholism: Review and subtypes identified in Han Chinese

Sheng Yu Lee, Shiou Lan Chen, Yun Hsuan Chang, Ru-Band Lu

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Alcoholism, as it has been hypothesized, is caused by a highly heterogeneous genetic load. Since 1960, many reports have used the bio-psycho-social approach to subtype alcoholism; however, no subtypes have been genetically validated. We reviewed and compared the major single-gene, multiple-gene, and gene-to-gene interaction studies on alcoholism published during the past quarter-century, including many recent studies that have made contributions to the subtyping of alcoholism. Four subtypes of alcoholism have been reported: [1] pure alcoholism, [2] anxiety/depression alcoholism, [3] antisocial alcoholism, and [4] mixed alcoholism. Most of the important studies focused on three genes: DRD2, MAOA, and ALDH2. Therefore, our review focuses on these three genes.

Original languageEnglish
Pages (from-to)36-40
Number of pages5
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume48
DOIs
Publication statusPublished - 2014 Jan 3

Fingerprint

Alcoholism
Genes
Genetic Load
Anxiety
Depression

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Biological Psychiatry

Cite this

Lee, Sheng Yu ; Chen, Shiou Lan ; Chang, Yun Hsuan ; Lu, Ru-Band. / Variation of types of alcoholism : Review and subtypes identified in Han Chinese. In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2014 ; Vol. 48. pp. 36-40.
@article{5a41787f6fb84a609d5a61f8415d7044,
title = "Variation of types of alcoholism: Review and subtypes identified in Han Chinese",
abstract = "Alcoholism, as it has been hypothesized, is caused by a highly heterogeneous genetic load. Since 1960, many reports have used the bio-psycho-social approach to subtype alcoholism; however, no subtypes have been genetically validated. We reviewed and compared the major single-gene, multiple-gene, and gene-to-gene interaction studies on alcoholism published during the past quarter-century, including many recent studies that have made contributions to the subtyping of alcoholism. Four subtypes of alcoholism have been reported: [1] pure alcoholism, [2] anxiety/depression alcoholism, [3] antisocial alcoholism, and [4] mixed alcoholism. Most of the important studies focused on three genes: DRD2, MAOA, and ALDH2. Therefore, our review focuses on these three genes.",
author = "Lee, {Sheng Yu} and Chen, {Shiou Lan} and Chang, {Yun Hsuan} and Ru-Band Lu",
year = "2014",
month = "1",
day = "3",
doi = "10.1016/j.pnpbp.2013.09.013",
language = "English",
volume = "48",
pages = "36--40",
journal = "Progress in Neuro-Psychopharmacology and Biological Psychiatry",
issn = "0278-5846",
publisher = "Elsevier Inc.",

}

Variation of types of alcoholism : Review and subtypes identified in Han Chinese. / Lee, Sheng Yu; Chen, Shiou Lan; Chang, Yun Hsuan; Lu, Ru-Band.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 48, 03.01.2014, p. 36-40.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Variation of types of alcoholism

T2 - Review and subtypes identified in Han Chinese

AU - Lee, Sheng Yu

AU - Chen, Shiou Lan

AU - Chang, Yun Hsuan

AU - Lu, Ru-Band

PY - 2014/1/3

Y1 - 2014/1/3

N2 - Alcoholism, as it has been hypothesized, is caused by a highly heterogeneous genetic load. Since 1960, many reports have used the bio-psycho-social approach to subtype alcoholism; however, no subtypes have been genetically validated. We reviewed and compared the major single-gene, multiple-gene, and gene-to-gene interaction studies on alcoholism published during the past quarter-century, including many recent studies that have made contributions to the subtyping of alcoholism. Four subtypes of alcoholism have been reported: [1] pure alcoholism, [2] anxiety/depression alcoholism, [3] antisocial alcoholism, and [4] mixed alcoholism. Most of the important studies focused on three genes: DRD2, MAOA, and ALDH2. Therefore, our review focuses on these three genes.

AB - Alcoholism, as it has been hypothesized, is caused by a highly heterogeneous genetic load. Since 1960, many reports have used the bio-psycho-social approach to subtype alcoholism; however, no subtypes have been genetically validated. We reviewed and compared the major single-gene, multiple-gene, and gene-to-gene interaction studies on alcoholism published during the past quarter-century, including many recent studies that have made contributions to the subtyping of alcoholism. Four subtypes of alcoholism have been reported: [1] pure alcoholism, [2] anxiety/depression alcoholism, [3] antisocial alcoholism, and [4] mixed alcoholism. Most of the important studies focused on three genes: DRD2, MAOA, and ALDH2. Therefore, our review focuses on these three genes.

UR - http://www.scopus.com/inward/record.url?scp=84884914144&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84884914144&partnerID=8YFLogxK

U2 - 10.1016/j.pnpbp.2013.09.013

DO - 10.1016/j.pnpbp.2013.09.013

M3 - Review article

C2 - 24080236

AN - SCOPUS:84884914144

VL - 48

SP - 36

EP - 40

JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry

SN - 0278-5846

ER -