Variation of types of alcoholism: Review and subtypes identified in Han Chinese

Sheng Yu Lee, Shiou Lan Chen, Yun Hsuan Chang, Ru-Band Lu

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)

Abstract

Alcoholism, as it has been hypothesized, is caused by a highly heterogeneous genetic load. Since 1960, many reports have used the bio-psycho-social approach to subtype alcoholism; however, no subtypes have been genetically validated. We reviewed and compared the major single-gene, multiple-gene, and gene-to-gene interaction studies on alcoholism published during the past quarter-century, including many recent studies that have made contributions to the subtyping of alcoholism. Four subtypes of alcoholism have been reported: [1] pure alcoholism, [2] anxiety/depression alcoholism, [3] antisocial alcoholism, and [4] mixed alcoholism. Most of the important studies focused on three genes: DRD2, MAOA, and ALDH2. Therefore, our review focuses on these three genes.

Original languageEnglish
Pages (from-to)36-40
Number of pages5
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume48
DOIs
Publication statusPublished - 2014 Jan 3

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Biological Psychiatry

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