Vigabatrin-attributable visual field defects in patients with intractable partial epilepsy

Yu Lung Tseng, Min Yu Lan, Shung Lon Lai, Fu Chin Huang, Jing Jane Tsai

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Introduction: Vigabatrin (VGB) is implicated to cause visual field defects. We estimated the prevalence, described the characteristics and investigated the risk factors of VGB-attributable visual field defects. Methods: Patients with intractable partial epilepsy under VGB add-on treatment received static perimetric examinations. Visual field charts were reviewed and interpreted using a three-grade system. Clinical features and therapeutic courses were analyzed for possible risk factors. Results: Visual field defects in at least one eye were detected in 27 (79%) of 34 patients. In the subgroup of 27 patients with both eyes reliably tested, 16 (59%) had bilateral defect, among whom seven were severely involved and showed nasally dominant, crescent or concentric defect. Five patients had unilateral visual field defects. Four out of the 27 affected patients reported blurred vision. No statistically significant differences were noted between patients with and without visual field defects in terms of gender, age, duration or etiology of the epilepsy, and duration, maximum daily dose, or cumulative dose of VGB. Conclusions: There was a high prevalence of VGB-attributable visual field defects. No risk factors could be identified. Routine initial and regular follow-up of visual field examination, especially that focusing within a range of central fixation to 60°, should be performed in patients on VGB.

Original languageEnglish
Pages (from-to)244-250
Number of pages7
JournalActa Neurologica Taiwanica
Volume15
Issue number4
Publication statusPublished - 2006 Dec 1

Fingerprint

Vigabatrin
Partial Epilepsy
Visual Fields
Drug Resistant Epilepsy
Epilepsy

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Tseng, Yu Lung ; Lan, Min Yu ; Lai, Shung Lon ; Huang, Fu Chin ; Tsai, Jing Jane. / Vigabatrin-attributable visual field defects in patients with intractable partial epilepsy. In: Acta Neurologica Taiwanica. 2006 ; Vol. 15, No. 4. pp. 244-250.
@article{b1769e9b706a41738ccbfee6bfaf4870,
title = "Vigabatrin-attributable visual field defects in patients with intractable partial epilepsy",
abstract = "Introduction: Vigabatrin (VGB) is implicated to cause visual field defects. We estimated the prevalence, described the characteristics and investigated the risk factors of VGB-attributable visual field defects. Methods: Patients with intractable partial epilepsy under VGB add-on treatment received static perimetric examinations. Visual field charts were reviewed and interpreted using a three-grade system. Clinical features and therapeutic courses were analyzed for possible risk factors. Results: Visual field defects in at least one eye were detected in 27 (79{\%}) of 34 patients. In the subgroup of 27 patients with both eyes reliably tested, 16 (59{\%}) had bilateral defect, among whom seven were severely involved and showed nasally dominant, crescent or concentric defect. Five patients had unilateral visual field defects. Four out of the 27 affected patients reported blurred vision. No statistically significant differences were noted between patients with and without visual field defects in terms of gender, age, duration or etiology of the epilepsy, and duration, maximum daily dose, or cumulative dose of VGB. Conclusions: There was a high prevalence of VGB-attributable visual field defects. No risk factors could be identified. Routine initial and regular follow-up of visual field examination, especially that focusing within a range of central fixation to 60°, should be performed in patients on VGB.",
author = "Tseng, {Yu Lung} and Lan, {Min Yu} and Lai, {Shung Lon} and Huang, {Fu Chin} and Tsai, {Jing Jane}",
year = "2006",
month = "12",
day = "1",
language = "English",
volume = "15",
pages = "244--250",
journal = "Acta Neurologica Taiwanica",
issn = "1019-6099",
publisher = "Taiwan Neurological Society",
number = "4",

}

Vigabatrin-attributable visual field defects in patients with intractable partial epilepsy. / Tseng, Yu Lung; Lan, Min Yu; Lai, Shung Lon; Huang, Fu Chin; Tsai, Jing Jane.

In: Acta Neurologica Taiwanica, Vol. 15, No. 4, 01.12.2006, p. 244-250.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Vigabatrin-attributable visual field defects in patients with intractable partial epilepsy

AU - Tseng, Yu Lung

AU - Lan, Min Yu

AU - Lai, Shung Lon

AU - Huang, Fu Chin

AU - Tsai, Jing Jane

PY - 2006/12/1

Y1 - 2006/12/1

N2 - Introduction: Vigabatrin (VGB) is implicated to cause visual field defects. We estimated the prevalence, described the characteristics and investigated the risk factors of VGB-attributable visual field defects. Methods: Patients with intractable partial epilepsy under VGB add-on treatment received static perimetric examinations. Visual field charts were reviewed and interpreted using a three-grade system. Clinical features and therapeutic courses were analyzed for possible risk factors. Results: Visual field defects in at least one eye were detected in 27 (79%) of 34 patients. In the subgroup of 27 patients with both eyes reliably tested, 16 (59%) had bilateral defect, among whom seven were severely involved and showed nasally dominant, crescent or concentric defect. Five patients had unilateral visual field defects. Four out of the 27 affected patients reported blurred vision. No statistically significant differences were noted between patients with and without visual field defects in terms of gender, age, duration or etiology of the epilepsy, and duration, maximum daily dose, or cumulative dose of VGB. Conclusions: There was a high prevalence of VGB-attributable visual field defects. No risk factors could be identified. Routine initial and regular follow-up of visual field examination, especially that focusing within a range of central fixation to 60°, should be performed in patients on VGB.

AB - Introduction: Vigabatrin (VGB) is implicated to cause visual field defects. We estimated the prevalence, described the characteristics and investigated the risk factors of VGB-attributable visual field defects. Methods: Patients with intractable partial epilepsy under VGB add-on treatment received static perimetric examinations. Visual field charts were reviewed and interpreted using a three-grade system. Clinical features and therapeutic courses were analyzed for possible risk factors. Results: Visual field defects in at least one eye were detected in 27 (79%) of 34 patients. In the subgroup of 27 patients with both eyes reliably tested, 16 (59%) had bilateral defect, among whom seven were severely involved and showed nasally dominant, crescent or concentric defect. Five patients had unilateral visual field defects. Four out of the 27 affected patients reported blurred vision. No statistically significant differences were noted between patients with and without visual field defects in terms of gender, age, duration or etiology of the epilepsy, and duration, maximum daily dose, or cumulative dose of VGB. Conclusions: There was a high prevalence of VGB-attributable visual field defects. No risk factors could be identified. Routine initial and regular follow-up of visual field examination, especially that focusing within a range of central fixation to 60°, should be performed in patients on VGB.

UR - http://www.scopus.com/inward/record.url?scp=33845958828&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845958828&partnerID=8YFLogxK

M3 - Review article

C2 - 17214087

AN - SCOPUS:33845958828

VL - 15

SP - 244

EP - 250

JO - Acta Neurologica Taiwanica

JF - Acta Neurologica Taiwanica

SN - 1019-6099

IS - 4

ER -