Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript

Guey Chuen Perng; Clinton Jones; Janice Ciacci-Zanella; Melissa Stone; Gail Henderson; Ada Yukht; Susan M. Slanina; Florence M. Hofman; Homayon Ghiasi; Anthony B. Nesburn; Steven L. Wechsler

doi:10.1126/science.287.5457.1500

Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript

Guey Chuen Perng, Clinton Jones, Janice Ciacci-Zanella, Melissa Stone, Gail Henderson, Ada Yukht, Susan M. Slanina, Florence M. Hofman, Homayon Ghiasi, Anthony B. Nesburn, Steven L. Wechsler

Institute of Basic Medical Sciences

Research output: Contribution to journal › Article › peer-review

399 Citations (Scopus)

Abstract

Latent infections with periodic reactivation are a common outcome after acute infection with many viruses. The latency-associated transcript (LAT) gene is required for wild-type reactivation of herpes simplex virus (HSV). However, the underlying mechanisms remain unclear. In rabbit trigeminal ganglia, extensive apoptosis occurred with LAT^- virus but not with LAT⁺ viruses. In addition, a plasmid expressing LAT blocked apoptosis in cultured cells. Thus, LAT promotes neuronal survival after HSV-1 infection by reducing apoptosis.

Original language	English
Pages (from-to)	1500-1503
Number of pages	4
Journal	Science
Volume	287
Issue number	5457
DOIs	https://doi.org/10.1126/science.287.5457.1500
Publication status	Published - 2000 Feb 25

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10.1126/science.287.5457.1500

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title = "Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript",

abstract = "Latent infections with periodic reactivation are a common outcome after acute infection with many viruses. The latency-associated transcript (LAT) gene is required for wild-type reactivation of herpes simplex virus (HSV). However, the underlying mechanisms remain unclear. In rabbit trigeminal ganglia, extensive apoptosis occurred with LAT- virus but not with LAT+ viruses. In addition, a plasmid expressing LAT blocked apoptosis in cultured cells. Thus, LAT promotes neuronal survival after HSV-1 infection by reducing apoptosis.",

author = "Perng, {Guey Chuen} and Clinton Jones and Janice Ciacci-Zanella and Melissa Stone and Gail Henderson and Ada Yukht and Slanina, {Susan M.} and Hofman, {Florence M.} and Homayon Ghiasi and Nesburn, {Anthony B.} and Wechsler, {Steven L.}",

year = "2000",

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doi = "10.1126/science.287.5457.1500",

language = "English",

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T1 - Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript

AU - Perng, Guey Chuen

AU - Jones, Clinton

AU - Ciacci-Zanella, Janice

AU - Stone, Melissa

AU - Henderson, Gail

AU - Yukht, Ada

AU - Slanina, Susan M.

AU - Hofman, Florence M.

AU - Ghiasi, Homayon

AU - Nesburn, Anthony B.

AU - Wechsler, Steven L.

PY - 2000/2/25

Y1 - 2000/2/25

N2 - Latent infections with periodic reactivation are a common outcome after acute infection with many viruses. The latency-associated transcript (LAT) gene is required for wild-type reactivation of herpes simplex virus (HSV). However, the underlying mechanisms remain unclear. In rabbit trigeminal ganglia, extensive apoptosis occurred with LAT- virus but not with LAT+ viruses. In addition, a plasmid expressing LAT blocked apoptosis in cultured cells. Thus, LAT promotes neuronal survival after HSV-1 infection by reducing apoptosis.

AB - Latent infections with periodic reactivation are a common outcome after acute infection with many viruses. The latency-associated transcript (LAT) gene is required for wild-type reactivation of herpes simplex virus (HSV). However, the underlying mechanisms remain unclear. In rabbit trigeminal ganglia, extensive apoptosis occurred with LAT- virus but not with LAT+ viruses. In addition, a plasmid expressing LAT blocked apoptosis in cultured cells. Thus, LAT promotes neuronal survival after HSV-1 infection by reducing apoptosis.

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ER -

Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript

Abstract

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