Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript

Guey Chuen Perng, Clinton Jones, Janice Ciacci-Zanella, Melissa Stone, Gail Henderson, Ada Yukht, Susan M. Slanina, Florence M. Hofman, Homayon Ghiasi, Anthony B. Nesburn, Steven L. Wechsler

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Abstract

Latent infections with periodic reactivation are a common outcome after acute infection with many viruses. The latency-associated transcript (LAT) gene is required for wild-type reactivation of herpes simplex virus (HSV). However, the underlying mechanisms remain unclear. In rabbit trigeminal ganglia, extensive apoptosis occurred with LAT- virus but not with LAT+ viruses. In addition, a plasmid expressing LAT blocked apoptosis in cultured cells. Thus, LAT promotes neuronal survival after HSV-1 infection by reducing apoptosis.

Original languageEnglish
Pages (from-to)1500-1503
Number of pages4
JournalScience
Volume287
Issue number5457
DOIs
Publication statusPublished - 2000 Feb 25

All Science Journal Classification (ASJC) codes

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    Perng, G. C., Jones, C., Ciacci-Zanella, J., Stone, M., Henderson, G., Yukht, A., Slanina, S. M., Hofman, F. M., Ghiasi, H., Nesburn, A. B., & Wechsler, S. L. (2000). Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript. Science, 287(5457), 1500-1503. https://doi.org/10.1126/science.287.5457.1500