Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript

Guey-Chuen Perng, Clinton Jones, Janice Ciacci-Zanella, Melissa Stone, Gail Henderson, Ada Yukht, Susan M. Slanina, Florence M. Hofman, Homayon Ghiasi, Anthony B. Nesburn, Steven L. Wechsler

Research output: Contribution to journalArticle

325 Citations (Scopus)

Abstract

Latent infections with periodic reactivation are a common outcome after acute infection with many viruses. The latency-associated transcript (LAT) gene is required for wild-type reactivation of herpes simplex virus (HSV). However, the underlying mechanisms remain unclear. In rabbit trigeminal ganglia, extensive apoptosis occurred with LAT- virus but not with LAT+ viruses. In addition, a plasmid expressing LAT blocked apoptosis in cultured cells. Thus, LAT promotes neuronal survival after HSV-1 infection by reducing apoptosis.

Original languageEnglish
Pages (from-to)1500-1503
Number of pages4
JournalScience
Volume287
Issue number5457
DOIs
Publication statusPublished - 2000 Feb 25

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Virus Latency
Simplexvirus
Satellite Viruses
Apoptosis
Viruses
Trigeminal Ganglion
Human Herpesvirus 1
Virus Diseases
Infection
Cultured Cells
Plasmids
Rabbits
Genes

All Science Journal Classification (ASJC) codes

  • General

Cite this

Perng, G-C., Jones, C., Ciacci-Zanella, J., Stone, M., Henderson, G., Yukht, A., ... Wechsler, S. L. (2000). Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript. Science, 287(5457), 1500-1503. https://doi.org/10.1126/science.287.5457.1500
Perng, Guey-Chuen ; Jones, Clinton ; Ciacci-Zanella, Janice ; Stone, Melissa ; Henderson, Gail ; Yukht, Ada ; Slanina, Susan M. ; Hofman, Florence M. ; Ghiasi, Homayon ; Nesburn, Anthony B. ; Wechsler, Steven L. / Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript. In: Science. 2000 ; Vol. 287, No. 5457. pp. 1500-1503.
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abstract = "Latent infections with periodic reactivation are a common outcome after acute infection with many viruses. The latency-associated transcript (LAT) gene is required for wild-type reactivation of herpes simplex virus (HSV). However, the underlying mechanisms remain unclear. In rabbit trigeminal ganglia, extensive apoptosis occurred with LAT- virus but not with LAT+ viruses. In addition, a plasmid expressing LAT blocked apoptosis in cultured cells. Thus, LAT promotes neuronal survival after HSV-1 infection by reducing apoptosis.",
author = "Guey-Chuen Perng and Clinton Jones and Janice Ciacci-Zanella and Melissa Stone and Gail Henderson and Ada Yukht and Slanina, {Susan M.} and Hofman, {Florence M.} and Homayon Ghiasi and Nesburn, {Anthony B.} and Wechsler, {Steven L.}",
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Perng, G-C, Jones, C, Ciacci-Zanella, J, Stone, M, Henderson, G, Yukht, A, Slanina, SM, Hofman, FM, Ghiasi, H, Nesburn, AB & Wechsler, SL 2000, 'Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript', Science, vol. 287, no. 5457, pp. 1500-1503. https://doi.org/10.1126/science.287.5457.1500

Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript. / Perng, Guey-Chuen; Jones, Clinton; Ciacci-Zanella, Janice; Stone, Melissa; Henderson, Gail; Yukht, Ada; Slanina, Susan M.; Hofman, Florence M.; Ghiasi, Homayon; Nesburn, Anthony B.; Wechsler, Steven L.

In: Science, Vol. 287, No. 5457, 25.02.2000, p. 1500-1503.

Research output: Contribution to journalArticle

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AU - Perng, Guey-Chuen

AU - Jones, Clinton

AU - Ciacci-Zanella, Janice

AU - Stone, Melissa

AU - Henderson, Gail

AU - Yukht, Ada

AU - Slanina, Susan M.

AU - Hofman, Florence M.

AU - Ghiasi, Homayon

AU - Nesburn, Anthony B.

AU - Wechsler, Steven L.

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N2 - Latent infections with periodic reactivation are a common outcome after acute infection with many viruses. The latency-associated transcript (LAT) gene is required for wild-type reactivation of herpes simplex virus (HSV). However, the underlying mechanisms remain unclear. In rabbit trigeminal ganglia, extensive apoptosis occurred with LAT- virus but not with LAT+ viruses. In addition, a plasmid expressing LAT blocked apoptosis in cultured cells. Thus, LAT promotes neuronal survival after HSV-1 infection by reducing apoptosis.

AB - Latent infections with periodic reactivation are a common outcome after acute infection with many viruses. The latency-associated transcript (LAT) gene is required for wild-type reactivation of herpes simplex virus (HSV). However, the underlying mechanisms remain unclear. In rabbit trigeminal ganglia, extensive apoptosis occurred with LAT- virus but not with LAT+ viruses. In addition, a plasmid expressing LAT blocked apoptosis in cultured cells. Thus, LAT promotes neuronal survival after HSV-1 infection by reducing apoptosis.

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