TY - JOUR
T1 - Viscoelastic characterization and modeling of polymer transducers for biological applications
AU - Lin, I. Kuan
AU - Ou, Kuang Shun
AU - Liao, Yen Ming
AU - Liu, Yan
AU - Chen, Kuo Shen
AU - Zhang, Xin
N1 - Funding Information:
Manuscript received December 24, 2008; revised May 6, 2009. First published September 11, 2009; current version published September 30, 2009. This work was supported in part by the National Science Foundation under Grants CMMI-0826191, CMMI-0239163 and CMMI-0700688 and in part by the National Science Council of Taiwan under Grant NSC96-2628-E-006-006-MY3. Subject Editor S. M. Spearing.
PY - 2009
Y1 - 2009
N2 - Polydimethylsiloxane (PDMS) is an important polymeric material widely used in bio-MEMS devices such as micropillar arrays for cellular mechanical force measurements. The accuracy of such a measurement relies on choosing an appropriate material constitutive model for converting the measured structural deformations into corresponding reaction forces. However, although PDMS is a well-known viscoelastic material, many researchers in the past have treated it as a linear elastic material, which could result in errors of cellular traction force interpretation. In this paper, the mechanical properties of PDMS were characterized by using uniaxial compression, dynamic mechanical analysis, and nanoindentation tests, as well as finite element analysis (FEA). A generalized Maxwell model with the use of two exponential terms was used to emulate the mechanical behavior of PDMS at room temperature. After we found the viscoelastic constitutive law of PDMS, we used it to develop a more accurate model for converting deflection data to cellular traction forces. Moreover, in situ cellular traction force evolutions of cardiac myocytes were demonstrated by using this new conversion model. The results presented by this paper are believed to be useful for biologists who are interpreting similar physiological processes.
AB - Polydimethylsiloxane (PDMS) is an important polymeric material widely used in bio-MEMS devices such as micropillar arrays for cellular mechanical force measurements. The accuracy of such a measurement relies on choosing an appropriate material constitutive model for converting the measured structural deformations into corresponding reaction forces. However, although PDMS is a well-known viscoelastic material, many researchers in the past have treated it as a linear elastic material, which could result in errors of cellular traction force interpretation. In this paper, the mechanical properties of PDMS were characterized by using uniaxial compression, dynamic mechanical analysis, and nanoindentation tests, as well as finite element analysis (FEA). A generalized Maxwell model with the use of two exponential terms was used to emulate the mechanical behavior of PDMS at room temperature. After we found the viscoelastic constitutive law of PDMS, we used it to develop a more accurate model for converting deflection data to cellular traction forces. Moreover, in situ cellular traction force evolutions of cardiac myocytes were demonstrated by using this new conversion model. The results presented by this paper are believed to be useful for biologists who are interpreting similar physiological processes.
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U2 - 10.1109/JMEMS.2009.2029166
DO - 10.1109/JMEMS.2009.2029166
M3 - Article
AN - SCOPUS:70349989950
VL - 18
SP - 1087
EP - 1099
JO - Journal of Microelectromechanical Systems
JF - Journal of Microelectromechanical Systems
SN - 1057-7157
IS - 5
ER -