Vitamin B6 alleviates the vascular complications of insulin-treated STZ-induced diabetic rats

Sue-Joan Chang, C. L. Chiang

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this study is to investigate whether vitamin B6 alleviates the vascular complications of insulin-treated streptozotocin (STZ)-induced diabetes in rats. Diabetic animals were treated with or without vitamin B6 and/or insulin. Platelet aggregation induced by ADP (10 μM) or thrombin (0.05 D/mL) was measured in platelet rich plasma of normal and diabetic animals. 14C-Thromboxane B2 (14C-TxB2) production of platelets, using 14C-Arachidonic Acid (14C-AA) as a precursor, was assayed by means of scanning radiochromatography and autoradiography. 14C-TxB2 was quantitied by scintillation counter. The results showed that vitamin B6 in conjuction with insulin treatment resulted in lower blood glucose than either vitamin B6 or insulin treatment alone. Similarly, platelet aggregation and TxB2 production in diabetics with vitamin B6 and insulin treatment were significantly decreased. These data indicated that vitamin B6 in conjunction with insulin treatment seemed to be better than vitamin B6 or insulin treatment alone in controlling blood glucose, inhibiting platelet aggregation and decreasing TxA2 production.

Original languageEnglish
Pages (from-to)235-248
Number of pages14
JournalNutritional Sciences Journal
Volume21
Issue number3
Publication statusPublished - 1996 Jan 1

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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