Background/Purpose: Surgery is one of the treatment choices for Graves disease. The residual thyroid tissue may shrink or become larger. The object of this study was trying to find out what factors affect the residual thyroid gland volume change after thyroidectomy in Graves disease. Methods: We followed thyroid volume changes by ultrasonography in 101 patients with Graves disease who underwent one side lobectomy and another side subtotal thyroidectomy from 1996 to 2006. These patients were divided into three groups according to the residual thyroid size increasing, no change in size, and shrinking. We checked the factors as follows: age, body weight, thyroid-stimulating hormone (TSH) level, TSH-receptor antibody level, anti-thyroid peroxidase (TPO) antibody level, total thyroid volume before and after thyroidectomy, and degree of lymphocyte infiltration. Results: We found that young age and lower residual volume ratio were the most powerful two factors affecting remnant thyroid gland volume changing. We also found that there is no significant correlation between TSH levels and thyroid volume change, nor TSH-receptor antibody titer or thyroid volume change. Conclusion: Age and residual volume ratio were the most powerful two factors in this study.
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