Volume replacement in infants with dengue hemorrhagic fever/dengue shock syndrome

Thanh Hung Nguyen, Trong Lan Nguyen, Huan Yao Lei, Yee Shin Lin, Bich Lien Le, Kao Jean Huang, Chiou Feng Lin, Quang Ha Do, Vu Thi Que Huong, Thi My Lam, Trai Ming Yeh, Jyh Hsiung Huang, Ching Chuan Liu, Scott B. Halstead

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Volume replacement was studied prospectively in 208 infants with dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). The mean volume of intravenous fluid used was 110.4 mL/kg administered over a mean period of 25.8 hours. The mean volumes of intravenous fluid replacement in infants with DSS was significantly higher than in those with non-shock DHF (129.8 mL/kg versus 102.1 mL/kg; P = 0.001). Patients with DSS had significantly higher proportional requirements for dextran and blood transfusions than non-shock infants. Recurrent shock, prolonged shock, and acute respiratory failure were recorded in 8, 6, and 13 patients, respectively. Four patients with DSS died of severe complications. Intravenous fluid replacement with special care to avoid fluid overload requires careful attention to established indications for use of colloidal solutions and blood transfusions. To improve case fatality rates, special efforts need to be directed to infants with DHF/DSS accompanied by severe complications.

Original languageEnglish
Pages (from-to)684-691
Number of pages8
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume74
Issue number4
Publication statusPublished - 2006 Apr 1

Fingerprint

Severe Dengue
Blood Transfusion
Shock
Dextrans
Respiratory Insufficiency
Mortality

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Virology
  • Infectious Diseases

Cite this

Nguyen, T. H., Nguyen, T. L., Lei, H. Y., Lin, Y. S., Le, B. L., Huang, K. J., ... Halstead, S. B. (2006). Volume replacement in infants with dengue hemorrhagic fever/dengue shock syndrome. American Journal of Tropical Medicine and Hygiene, 74(4), 684-691.
Nguyen, Thanh Hung ; Nguyen, Trong Lan ; Lei, Huan Yao ; Lin, Yee Shin ; Le, Bich Lien ; Huang, Kao Jean ; Lin, Chiou Feng ; Do, Quang Ha ; Huong, Vu Thi Que ; Lam, Thi My ; Yeh, Trai Ming ; Huang, Jyh Hsiung ; Liu, Ching Chuan ; Halstead, Scott B. / Volume replacement in infants with dengue hemorrhagic fever/dengue shock syndrome. In: American Journal of Tropical Medicine and Hygiene. 2006 ; Vol. 74, No. 4. pp. 684-691.
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Nguyen, TH, Nguyen, TL, Lei, HY, Lin, YS, Le, BL, Huang, KJ, Lin, CF, Do, QH, Huong, VTQ, Lam, TM, Yeh, TM, Huang, JH, Liu, CC & Halstead, SB 2006, 'Volume replacement in infants with dengue hemorrhagic fever/dengue shock syndrome', American Journal of Tropical Medicine and Hygiene, vol. 74, no. 4, pp. 684-691.

Volume replacement in infants with dengue hemorrhagic fever/dengue shock syndrome. / Nguyen, Thanh Hung; Nguyen, Trong Lan; Lei, Huan Yao; Lin, Yee Shin; Le, Bich Lien; Huang, Kao Jean; Lin, Chiou Feng; Do, Quang Ha; Huong, Vu Thi Que; Lam, Thi My; Yeh, Trai Ming; Huang, Jyh Hsiung; Liu, Ching Chuan; Halstead, Scott B.

In: American Journal of Tropical Medicine and Hygiene, Vol. 74, No. 4, 01.04.2006, p. 684-691.

Research output: Contribution to journalArticle

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T1 - Volume replacement in infants with dengue hemorrhagic fever/dengue shock syndrome

AU - Nguyen, Thanh Hung

AU - Nguyen, Trong Lan

AU - Lei, Huan Yao

AU - Lin, Yee Shin

AU - Le, Bich Lien

AU - Huang, Kao Jean

AU - Lin, Chiou Feng

AU - Do, Quang Ha

AU - Huong, Vu Thi Que

AU - Lam, Thi My

AU - Yeh, Trai Ming

AU - Huang, Jyh Hsiung

AU - Liu, Ching Chuan

AU - Halstead, Scott B.

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