Wireless and batteryless biomedical microsystem for neural recording and epilepsy suppression based on brain focal cooling

K. C. Hou, C. W. Chang, J. C. Chiou, Y. H. Huang, F. Z. Shaw

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

This work presents a biomedical microsystem with a wireless radiofrequency (RF)-powered electronics and versatile sensors/actuators for use in nanomedicinal diagnosis and therapy. The cooling of brain tissue has the potential to reduce the frequency and severity of epilepsy. Miniaturised spiral coils as a wireless power module with low-dropout linear regulator circuit convert RF signals into a DC voltage, can be implanted without a battery in monitoring free behaviour. A thermoelectric (TE) cooler is an actuator that is employed to cool down brain tissue to suppress epilepsy. Electroencephalogram (EEG) electrodes and TE coolers are integrated to form module that is placed inside the head of a rat and fastened with a bio-compatible material. EEG signals are used to identify waveforms associated with epilepsy and are measured using readout circuits. The wireless part of the presented design achieves a low quiescent current and line/load regulation and high antenna/current efficiency with thermal protection to avoid damage to the implanted tissue. Epilepsy is suppressed by reducing the temperature to reduce the duration of this epileptic episode. Related characterisations demonstrate that the proposed design can be adopted in an effective nanomedicine microsystem.

Original languageEnglish
Pages (from-to)143-147
Number of pages5
JournalIET Nanobiotechnology
Volume5
Issue number4
DOIs
Publication statusPublished - 2011 Dec 1

Fingerprint

Microsystems
Epilepsy
Brain
Tissue
Electroencephalography
Cooling
Actuators
Medical nanotechnology
Networks (circuits)
Nanomedicine
Biomaterials
Rats
Electronic equipment
Antennas
Electrodes
Monitoring
Hot Temperature
Head
Sensors
Electric potential

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biotechnology
  • Electrical and Electronic Engineering
  • Psychology(all)

Cite this

@article{c3b173b20bcb4aa7bd9ba34204bc8cbf,
title = "Wireless and batteryless biomedical microsystem for neural recording and epilepsy suppression based on brain focal cooling",
abstract = "This work presents a biomedical microsystem with a wireless radiofrequency (RF)-powered electronics and versatile sensors/actuators for use in nanomedicinal diagnosis and therapy. The cooling of brain tissue has the potential to reduce the frequency and severity of epilepsy. Miniaturised spiral coils as a wireless power module with low-dropout linear regulator circuit convert RF signals into a DC voltage, can be implanted without a battery in monitoring free behaviour. A thermoelectric (TE) cooler is an actuator that is employed to cool down brain tissue to suppress epilepsy. Electroencephalogram (EEG) electrodes and TE coolers are integrated to form module that is placed inside the head of a rat and fastened with a bio-compatible material. EEG signals are used to identify waveforms associated with epilepsy and are measured using readout circuits. The wireless part of the presented design achieves a low quiescent current and line/load regulation and high antenna/current efficiency with thermal protection to avoid damage to the implanted tissue. Epilepsy is suppressed by reducing the temperature to reduce the duration of this epileptic episode. Related characterisations demonstrate that the proposed design can be adopted in an effective nanomedicine microsystem.",
author = "Hou, {K. C.} and Chang, {C. W.} and Chiou, {J. C.} and Huang, {Y. H.} and Shaw, {F. Z.}",
year = "2011",
month = "12",
day = "1",
doi = "10.1049/iet-nbt.2011.0017",
language = "English",
volume = "5",
pages = "143--147",
journal = "IET Nanobiotechnology",
issn = "1751-8741",
publisher = "Institution of Engineering and Technology",
number = "4",

}

Wireless and batteryless biomedical microsystem for neural recording and epilepsy suppression based on brain focal cooling. / Hou, K. C.; Chang, C. W.; Chiou, J. C.; Huang, Y. H.; Shaw, F. Z.

In: IET Nanobiotechnology, Vol. 5, No. 4, 01.12.2011, p. 143-147.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Wireless and batteryless biomedical microsystem for neural recording and epilepsy suppression based on brain focal cooling

AU - Hou, K. C.

AU - Chang, C. W.

AU - Chiou, J. C.

AU - Huang, Y. H.

AU - Shaw, F. Z.

PY - 2011/12/1

Y1 - 2011/12/1

N2 - This work presents a biomedical microsystem with a wireless radiofrequency (RF)-powered electronics and versatile sensors/actuators for use in nanomedicinal diagnosis and therapy. The cooling of brain tissue has the potential to reduce the frequency and severity of epilepsy. Miniaturised spiral coils as a wireless power module with low-dropout linear regulator circuit convert RF signals into a DC voltage, can be implanted without a battery in monitoring free behaviour. A thermoelectric (TE) cooler is an actuator that is employed to cool down brain tissue to suppress epilepsy. Electroencephalogram (EEG) electrodes and TE coolers are integrated to form module that is placed inside the head of a rat and fastened with a bio-compatible material. EEG signals are used to identify waveforms associated with epilepsy and are measured using readout circuits. The wireless part of the presented design achieves a low quiescent current and line/load regulation and high antenna/current efficiency with thermal protection to avoid damage to the implanted tissue. Epilepsy is suppressed by reducing the temperature to reduce the duration of this epileptic episode. Related characterisations demonstrate that the proposed design can be adopted in an effective nanomedicine microsystem.

AB - This work presents a biomedical microsystem with a wireless radiofrequency (RF)-powered electronics and versatile sensors/actuators for use in nanomedicinal diagnosis and therapy. The cooling of brain tissue has the potential to reduce the frequency and severity of epilepsy. Miniaturised spiral coils as a wireless power module with low-dropout linear regulator circuit convert RF signals into a DC voltage, can be implanted without a battery in monitoring free behaviour. A thermoelectric (TE) cooler is an actuator that is employed to cool down brain tissue to suppress epilepsy. Electroencephalogram (EEG) electrodes and TE coolers are integrated to form module that is placed inside the head of a rat and fastened with a bio-compatible material. EEG signals are used to identify waveforms associated with epilepsy and are measured using readout circuits. The wireless part of the presented design achieves a low quiescent current and line/load regulation and high antenna/current efficiency with thermal protection to avoid damage to the implanted tissue. Epilepsy is suppressed by reducing the temperature to reduce the duration of this epileptic episode. Related characterisations demonstrate that the proposed design can be adopted in an effective nanomedicine microsystem.

UR - http://www.scopus.com/inward/record.url?scp=82955171674&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=82955171674&partnerID=8YFLogxK

U2 - 10.1049/iet-nbt.2011.0017

DO - 10.1049/iet-nbt.2011.0017

M3 - Article

C2 - 22149871

AN - SCOPUS:82955171674

VL - 5

SP - 143

EP - 147

JO - IET Nanobiotechnology

JF - IET Nanobiotechnology

SN - 1751-8741

IS - 4

ER -