WSSV-induced crayfish Dscam shows durable immune behavior

Tze Hann Ng, Hsin Yi Hung, Yi An Chiang, Jia Hung Lin, Yi Ning Chen, Ya Chu Chuang, Han-Ching Wang

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

One of the major gaps in our understanding of arthropod specific immune priming concerns the mechanism[s] by which the observed long-term (>2 weeks) protective effects might be mediated. Hypervariable Dscam (Down syndrome cell adhesion molecule) might support arthropod innate immunity with specificity for more extended periods. We show here that, in the relatively long-lived arthropod Cherax quadricarinatus, CqDscam does not behave like a typical, immediately-acting, short-lived innate immune factor: CqDscam was not induced within hours after challenge with a lethal virus, but instead was only up-regulated after 2-5 days. This initial response faded within ~2 weeks, but another maximum was reached ~1 month later. At around 2 months after the initial challenge, the virus-induced CqDscam bound to the virus virion and acted to neutralize the virus However, although CqDscam helped crayfish to survive during persistent infection, it nevertheless failed to provide any enhanced protection against a subsequent WSSV challenge. Thus, CqDscam is capable of supporting extended anti-virus immune memory in arthropods. Also, during a persistent virus infection, the balance of "immune firepower" in crayfish appears to be altered such that the general immune factors become depleted while CqDscam becomes relatively predominant.

Original languageEnglish
Pages (from-to)78-90
Number of pages13
JournalFish and Shellfish Immunology
Volume40
Issue number1
DOIs
Publication statusPublished - 2014 Jan 1

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Down syndrome
Cell Adhesion Molecules
crayfish
adhesion
Viruses
cell adhesion
virus
viruses
arthropod
arthropods
Immunologic Factors
Cherax quadricarinatus
immunity
virion
infection
protective effect
Data storage equipment

All Science Journal Classification (ASJC) codes

  • Environmental Chemistry
  • Aquatic Science

Cite this

Ng, T. H., Hung, H. Y., Chiang, Y. A., Lin, J. H., Chen, Y. N., Chuang, Y. C., & Wang, H-C. (2014). WSSV-induced crayfish Dscam shows durable immune behavior. Fish and Shellfish Immunology, 40(1), 78-90. https://doi.org/10.1016/j.fsi.2014.06.023
Ng, Tze Hann ; Hung, Hsin Yi ; Chiang, Yi An ; Lin, Jia Hung ; Chen, Yi Ning ; Chuang, Ya Chu ; Wang, Han-Ching. / WSSV-induced crayfish Dscam shows durable immune behavior. In: Fish and Shellfish Immunology. 2014 ; Vol. 40, No. 1. pp. 78-90.
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Ng, TH, Hung, HY, Chiang, YA, Lin, JH, Chen, YN, Chuang, YC & Wang, H-C 2014, 'WSSV-induced crayfish Dscam shows durable immune behavior', Fish and Shellfish Immunology, vol. 40, no. 1, pp. 78-90. https://doi.org/10.1016/j.fsi.2014.06.023

WSSV-induced crayfish Dscam shows durable immune behavior. / Ng, Tze Hann; Hung, Hsin Yi; Chiang, Yi An; Lin, Jia Hung; Chen, Yi Ning; Chuang, Ya Chu; Wang, Han-Ching.

In: Fish and Shellfish Immunology, Vol. 40, No. 1, 01.01.2014, p. 78-90.

Research output: Contribution to journalArticle

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Ng TH, Hung HY, Chiang YA, Lin JH, Chen YN, Chuang YC et al. WSSV-induced crayfish Dscam shows durable immune behavior. Fish and Shellfish Immunology. 2014 Jan 1;40(1):78-90. https://doi.org/10.1016/j.fsi.2014.06.023