X-ray microbeams: Tumor therapy and central nervous system research

F. A. Dilmanian, Y. Qu, S. Liu, C. D. Cool, J. Gilbert, J. F. Hainfeld, C. A. Kruse, J. Laterra, D. Lenihan, M. M. Nawrocky, G. Pappas, Chun-I Sze, T. Yuasa, N. Zhong, Z. Zhong, J. W. McDonald

Research output: Contribution to journalConference article

48 Citations (Scopus)

Abstract

Irradiation with parallel arrays of thin, planar slices of X-ray beams (microplanar beams, or microbeams) spares normal tissue, including the central nervous system (CNS), and preferentially damages tumors. The effects are mediated, at least in part, by the tissue's microvasculature that seems to effectively repair itself in normal tissue but fails to do so in tumors. Consequently, the therapeutic index of single-fraction unidirectional microbeam irradiations has been shown to be larger than that of single-fraction unidirectional unsegmented beams in treating the intracranial rat 9L gliosarcoma tumor model (9LGS) and the subcutaneous murine mammary carcinoma EMT-6. This paper presents results demonstrating that individual microbeams, or arrays of parallel ones, can also be used for targeted, selective cell ablation in the CNS, and also to induce demyelination. The results highlight the value of the method as a powerful tool for studying the CNS through selective cell ablation, besides its potential as a treatment modality in clinical oncology.

Original languageEnglish
Pages (from-to)30-37
Number of pages8
JournalNuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
Volume548
Issue number1-2
DOIs
Publication statusPublished - 2005 Aug 11
EventProceedings of the 4th International Worhshop on Medical Applications of Synchrotron Radiation MASR 2004 -
Duration: 2005 Sep 232005 Sep 25

Fingerprint

central nervous system
microbeams
Neurology
Tumors
therapy
tumors
Tissue
Ablation
X rays
ablation
Irradiation
irradiation
x rays
Oncology
cells
rats
Rats
Repair
cancer
damage

All Science Journal Classification (ASJC) codes

  • Nuclear and High Energy Physics
  • Instrumentation

Cite this

Dilmanian, F. A. ; Qu, Y. ; Liu, S. ; Cool, C. D. ; Gilbert, J. ; Hainfeld, J. F. ; Kruse, C. A. ; Laterra, J. ; Lenihan, D. ; Nawrocky, M. M. ; Pappas, G. ; Sze, Chun-I ; Yuasa, T. ; Zhong, N. ; Zhong, Z. ; McDonald, J. W. / X-ray microbeams : Tumor therapy and central nervous system research. In: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 2005 ; Vol. 548, No. 1-2. pp. 30-37.
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Dilmanian, FA, Qu, Y, Liu, S, Cool, CD, Gilbert, J, Hainfeld, JF, Kruse, CA, Laterra, J, Lenihan, D, Nawrocky, MM, Pappas, G, Sze, C-I, Yuasa, T, Zhong, N, Zhong, Z & McDonald, JW 2005, 'X-ray microbeams: Tumor therapy and central nervous system research', Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, vol. 548, no. 1-2, pp. 30-37. https://doi.org/10.1016/j.nima.2005.03.062

X-ray microbeams : Tumor therapy and central nervous system research. / Dilmanian, F. A.; Qu, Y.; Liu, S.; Cool, C. D.; Gilbert, J.; Hainfeld, J. F.; Kruse, C. A.; Laterra, J.; Lenihan, D.; Nawrocky, M. M.; Pappas, G.; Sze, Chun-I; Yuasa, T.; Zhong, N.; Zhong, Z.; McDonald, J. W.

In: Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol. 548, No. 1-2, 11.08.2005, p. 30-37.

Research output: Contribution to journalConference article

TY - JOUR

T1 - X-ray microbeams

T2 - Tumor therapy and central nervous system research

AU - Dilmanian, F. A.

AU - Qu, Y.

AU - Liu, S.

AU - Cool, C. D.

AU - Gilbert, J.

AU - Hainfeld, J. F.

AU - Kruse, C. A.

AU - Laterra, J.

AU - Lenihan, D.

AU - Nawrocky, M. M.

AU - Pappas, G.

AU - Sze, Chun-I

AU - Yuasa, T.

AU - Zhong, N.

AU - Zhong, Z.

AU - McDonald, J. W.

PY - 2005/8/11

Y1 - 2005/8/11

N2 - Irradiation with parallel arrays of thin, planar slices of X-ray beams (microplanar beams, or microbeams) spares normal tissue, including the central nervous system (CNS), and preferentially damages tumors. The effects are mediated, at least in part, by the tissue's microvasculature that seems to effectively repair itself in normal tissue but fails to do so in tumors. Consequently, the therapeutic index of single-fraction unidirectional microbeam irradiations has been shown to be larger than that of single-fraction unidirectional unsegmented beams in treating the intracranial rat 9L gliosarcoma tumor model (9LGS) and the subcutaneous murine mammary carcinoma EMT-6. This paper presents results demonstrating that individual microbeams, or arrays of parallel ones, can also be used for targeted, selective cell ablation in the CNS, and also to induce demyelination. The results highlight the value of the method as a powerful tool for studying the CNS through selective cell ablation, besides its potential as a treatment modality in clinical oncology.

AB - Irradiation with parallel arrays of thin, planar slices of X-ray beams (microplanar beams, or microbeams) spares normal tissue, including the central nervous system (CNS), and preferentially damages tumors. The effects are mediated, at least in part, by the tissue's microvasculature that seems to effectively repair itself in normal tissue but fails to do so in tumors. Consequently, the therapeutic index of single-fraction unidirectional microbeam irradiations has been shown to be larger than that of single-fraction unidirectional unsegmented beams in treating the intracranial rat 9L gliosarcoma tumor model (9LGS) and the subcutaneous murine mammary carcinoma EMT-6. This paper presents results demonstrating that individual microbeams, or arrays of parallel ones, can also be used for targeted, selective cell ablation in the CNS, and also to induce demyelination. The results highlight the value of the method as a powerful tool for studying the CNS through selective cell ablation, besides its potential as a treatment modality in clinical oncology.

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M3 - Conference article

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VL - 548

SP - 30

EP - 37

JO - Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

JF - Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

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