ZBRK1 acts as a metastatic suppressor by directly regulating MMP9 in cervical cancer

Li Fang Lin, Chih Hung Chuang, Chien Feng Li, Ching Chun Liao, Chun Pei Cheng, Tian Lu Cheng, Meng-Ru Shen, Ta-Chien Tseng, Wen Chang, Wen Hwa Lee, Ju-Ming Wang

Research output: Contribution to journalArticle

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Abstract

The BRCA1-interacted transcriptional repressor ZBRK1 has been associated with antiangiogenesis, but direct evidence of a tumor suppressor role has been lacking. In this study, we provide evidence of such a role in cervical carcinoma. ZBRK1 levels in cervical tumor cells were significantly lower than in normal cervical epithelial cells. In HeLa cervical cancer cells, enforced expression inhibited malignant growth, invasion, and metastasis in a variety of in vitro and in vivo assays. Expression of the metalloproteinase MMP9, which is known to be an important driver of invasion and metastasis, was found to be inversely correlated with ZBRK1 in tumor tissues and a target for repression in tumor cells. Our findings suggest that ZBRK1 acts to inhibit metastasis of cervical carcinoma, perhaps by modulating MMP9 expression.

Original languageEnglish
Pages (from-to)192-201
Number of pages10
JournalCancer Research
Volume70
Issue number1
DOIs
Publication statusPublished - 2010 Jan 1

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Uterine Cervical Neoplasms
Neoplasm Metastasis
Neoplasms
Carcinoma
Matrix Metalloproteinase 9
Epithelial Cells
Growth

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Lin, Li Fang ; Chuang, Chih Hung ; Li, Chien Feng ; Liao, Ching Chun ; Cheng, Chun Pei ; Cheng, Tian Lu ; Shen, Meng-Ru ; Tseng, Ta-Chien ; Chang, Wen ; Lee, Wen Hwa ; Wang, Ju-Ming. / ZBRK1 acts as a metastatic suppressor by directly regulating MMP9 in cervical cancer. In: Cancer Research. 2010 ; Vol. 70, No. 1. pp. 192-201.
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Lin, LF, Chuang, CH, Li, CF, Liao, CC, Cheng, CP, Cheng, TL, Shen, M-R, Tseng, T-C, Chang, W, Lee, WH & Wang, J-M 2010, 'ZBRK1 acts as a metastatic suppressor by directly regulating MMP9 in cervical cancer', Cancer Research, vol. 70, no. 1, pp. 192-201. https://doi.org/10.1158/0008-5472.CAN-09-2641

ZBRK1 acts as a metastatic suppressor by directly regulating MMP9 in cervical cancer. / Lin, Li Fang; Chuang, Chih Hung; Li, Chien Feng; Liao, Ching Chun; Cheng, Chun Pei; Cheng, Tian Lu; Shen, Meng-Ru; Tseng, Ta-Chien; Chang, Wen; Lee, Wen Hwa; Wang, Ju-Ming.

In: Cancer Research, Vol. 70, No. 1, 01.01.2010, p. 192-201.

Research output: Contribution to journalArticle

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