Zfra is a small wizard in the mitochondrial apoptosis

Subhan Dudekula, Ming Hui Lee, Li-Jin Hsu, Shean Jen Chen, Nan-Shan Chang

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Zfra (zinc finger-like protein that regulates apoptosis) is a naturally occurring short peptide consisting of 31 amino acids, which regulates tumor necrosis factor (TNF)-mediated cell death by interacting with receptor adaptor protein TRADD (TNF receptorassociated death domain protein) and downstream JNK (c-Jun N-terminal kinase), NF-κB (Nuclear factor kappa B) and WWOX/WOX1 (WW domain-containing oxidoreductase). Cytochrome c release is generally considered as a pivotal step in apoptosis. Remarkably, overexpressed Zfra induces apoptosis via the mitochondrial pathway, which involves suppression of Bcl-2 and Bcl-xL expression (without causing cytochrome c release), counteracting the apoptotic function of tumor suppressor p53 and WWOX, and dissipation of mitochondrial membrane potential for ultimately leading to cell death. Control of cellular aging and apoptosis by Zfra, p53 and WWOX is discussed.

Original languageEnglish
Pages (from-to)1023-1029
Number of pages7
JournalAging
Volume2
Issue number12
DOIs
Publication statusPublished - 2010 Jan 1

Fingerprint

Apoptosis
Cytochromes c
Cell Death
Tumor Necrosis Factor-alpha
Proteins
JNK Mitogen-Activated Protein Kinases
NF-kappa B
Mitochondrial Membrane Potential
Cell Aging
Zinc Fingers
Oxidoreductases
Amino Acids
Peptides
Neoplasms
Death Domain

All Science Journal Classification (ASJC) codes

  • Ageing
  • Cell Biology

Cite this

Dudekula, Subhan ; Lee, Ming Hui ; Hsu, Li-Jin ; Chen, Shean Jen ; Chang, Nan-Shan. / Zfra is a small wizard in the mitochondrial apoptosis. In: Aging. 2010 ; Vol. 2, No. 12. pp. 1023-1029.
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Zfra is a small wizard in the mitochondrial apoptosis. / Dudekula, Subhan; Lee, Ming Hui; Hsu, Li-Jin; Chen, Shean Jen; Chang, Nan-Shan.

In: Aging, Vol. 2, No. 12, 01.01.2010, p. 1023-1029.

Research output: Contribution to journalArticle

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