Zika Virus Dependence on Host Hsp70 Provides a Protective Strategy against Infection and Disease

Shuhei Taguwa; Ming Te Yeh; T. Kelly Rainbolt; Arabinda Nayak; Hao Shao; Jason E. Gestwicki; Raul Andino; Judith Frydman

doi:10.1016/j.celrep.2018.12.095

Zika Virus Dependence on Host Hsp70 Provides a Protective Strategy against Infection and Disease

Shuhei Taguwa
, Ming Te Yeh
, T. Kelly Rainbolt
, Arabinda Nayak
, Hao Shao
, Jason E. Gestwicki
, Raul Andino
, Judith Frydman

Department of Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

89 Citations (Scopus)

Abstract

Hsp70 inhibitors effectively block Zika virus replication in both human and mosquito cells, without the emergence of drug resistance, and protect mice from lethal ZIKV infection, demonstrating their potential for treatment and prevention of ZIKV disease.

Original language	English
Pages (from-to)	906-920.e3
Journal	Cell Reports
Volume	26
Issue number	4
DOIs	https://doi.org/10.1016/j.celrep.2018.12.095
Publication status	Published - 2019 Jan 22

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

General Biochemistry,Genetics and Molecular Biology

Access to Document

10.1016/j.celrep.2018.12.095

Cite this

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title = "Zika Virus Dependence on Host Hsp70 Provides a Protective Strategy against Infection and Disease",

abstract = "Hsp70 inhibitors effectively block Zika virus replication in both human and mosquito cells, without the emergence of drug resistance, and protect mice from lethal ZIKV infection, demonstrating their potential for treatment and prevention of ZIKV disease.",

author = "Shuhei Taguwa and Yeh, \{Ming Te\} and Rainbolt, \{T. Kelly\} and Arabinda Nayak and Hao Shao and Gestwicki, \{Jason E.\} and Raul Andino and Judith Frydman",

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AU - Taguwa, Shuhei

AU - Yeh, Ming Te

AU - Rainbolt, T. Kelly

AU - Nayak, Arabinda

AU - Shao, Hao

AU - Gestwicki, Jason E.

AU - Andino, Raul

AU - Frydman, Judith

PY - 2019/1/22

Y1 - 2019/1/22

N2 - Hsp70 inhibitors effectively block Zika virus replication in both human and mosquito cells, without the emergence of drug resistance, and protect mice from lethal ZIKV infection, demonstrating their potential for treatment and prevention of ZIKV disease.

AB - Hsp70 inhibitors effectively block Zika virus replication in both human and mosquito cells, without the emergence of drug resistance, and protect mice from lethal ZIKV infection, demonstrating their potential for treatment and prevention of ZIKV disease.

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UR - https://www.scopus.com/pages/publications/85059821926#tab=citedBy

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M3 - Article

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AN - SCOPUS:85059821926

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VL - 26

SP - 906-920.e3

JO - Cell Reports

JF - Cell Reports

IS - 4

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Zika Virus Dependence on Host Hsp70 Provides a Protective Strategy against Infection and Disease

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

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