Zinc finger proteins in cancer progression

Jayu Jen, Yi Ching Wang

Research output: Contribution to journalReview articlepeer-review

95 Citations (Scopus)

Abstract

Zinc finger proteins are the largest transcription factor family in human genome. The diverse combinations and functions of zinc finger motifs make zinc finger proteins versatile in biological processes, including development, differentiation, metabolism and autophagy. Over the last few decades, increasing evidence reveals the potential roles of zinc finger proteins in cancer progression. However, the underlying mechanisms of zinc finger proteins in cancer progression vary in different cancer types and even in the same cancer type under different types of stress. Here, we discuss general mechanisms of zinc finger proteins in transcription regulation and summarize recent studies on zinc finger proteins in cancer progression. In this review, we also emphasize the importance of further investigations in elucidating the underlying mechanisms of zinc finger proteins in cancer progression.

Original languageEnglish
Article number53
JournalJournal of biomedical science
Volume23
Issue number1
DOIs
Publication statusPublished - 2016 Jul 13

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Zinc finger proteins in cancer progression'. Together they form a unique fingerprint.

Cite this